TRITIATED PEPTIDES .7. SYNTHESIS OF [2,5-H-3(2)-HIS6]-BETA-CORTICOTROPHIN-(1-24)-TETRACOSAPEPTIDE

被引：13
作者：
ALLEN, MC [1 ]
BRUNDISH, DE [1 ]
WADE, R [1 ]
机构：
[1] CIBA LABS,HORSHAM RH12 4AB,SUSSEX,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1979年 / 08期
关键词：
D O I：
10.1039/p19790002057
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis is described of β-corticotrophin-(1-24)-tetracosapeptide ‡ labelled with tritium in the histidine residue at position 6 at a specific radioactivity of 30 Ci mmol-1 by reductive dehalogenation of a protected precursor. Evidence for the integrity of the final product is provided by amino-acid analysis, column chromatography, and bioassay, supported by chemical and enzymic analytical data on the protected precursor and the derived free peptide containing di-iodohistidine.
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页码：2057 / 2063
页数：7
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