TRITIATED PEPTIDES .7. SYNTHESIS OF [2,5-H-3(2)-HIS6]-BETA-CORTICOTROPHIN-(1-24)-TETRACOSAPEPTIDE

被引：13

作者：

ALLEN, MC ^{[1
]}

BRUNDISH, DE ^{[1
]}

WADE, R ^{[1
]}

机构：

[1] CIBA LABS,HORSHAM RH12 4AB,SUSSEX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1979年 / 08期

关键词：

D O I：

10.1039/p19790002057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis is described of β-corticotrophin-(1-24)-tetracosapeptide ‡ labelled with tritium in the histidine residue at position 6 at a specific radioactivity of 30 Ci mmol-1 by reductive dehalogenation of a protected precursor. Evidence for the integrity of the final product is provided by amino-acid analysis, column chromatography, and bioassay, supported by chemical and enzymic analytical data on the protected precursor and the derived free peptide containing di-iodohistidine.

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页码：2057 / 2063

页数：7

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