ALPHA-MELANOCYTE-STIMULATING HORMONE - REDUCTION IN ADULT-RAT BRAIN AFTER MONOSODIUM GLUTAMATE TREATMENT OF NEONATES

被引：68
作者：
ESKAY, RL
BROWNSTEIN, MJ
LONG, RT
机构：
[1] Laboratory of Clinical Science, National Institute of Mental Health, Bethesda
来源：
SCIENCE | 1979年 / 205卷 / 4408期
关键词：
D O I：
10.1126/science.462194
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Intraperitoneal injection of monosodium glutamate in neonatal rats resulted in a 90 percent loss of α-melanocyte-stimulating hormone in hypothalamic and extrahypothalamic areas of the brain, whereas the amount of hormone in the pituitary gland did not change. The dramatic reduction of α-melanocyte- stimulating hormone in the brain suggests that its primary source there is the neuronal perikarya of the arcuate nucleus. Copyright © 1979 AAAS.
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页码：827 / 829
页数：3
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