Analysis of the action of Himatanthus drasticus in progression of urethane-induced lung cancer in mice

被引：0
|
作者：
de Souza Costa Franca, Wendy Caroline [1 ]
Lopes Amaral de Souza, Ana Claudia Rodrigues [1 ]
Cordeiro, Jose Antonio [1 ]
Cury, Patricia Maluf [1 ]
机构：
[1] Fac Med Sao Jose do Rio Preto, Av Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose do Rio Preto, SP, Brazil
来源：
EINSTEIN-SAO PAULO | 2011年 / 9卷 / 03期
关键词：
Lung neoplasms; Mice; Urethane; Phytotherapy; experimental;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To evaluate the effect of janaguba in inhibiting the development of lung cancer in an experimental urethane-induced model. Methods: a total of 3 mg/kg urethane was injected in 51 Balb-C mice aged 7-13 weeks of life. Janaguba was administered orally daily in two doses: 0.04 mL (Group 2, G2) and 0.06 mL (Group 3, G3), for 20 weeks. After this period, the mice were sacrificed and the number of lesions counted. Results: The mean weight of Group 2 was lower than that of Group 3, and that of Group 1 (Control, G1) (G1 = 35.533 g; G2 = 33.359 g; G3 = 37.125 g). The number of nodules did not differ between groups (mean G1 = G2 = G3 = 1; p = 0.88). Conclusion: Janaguba had an effect on the growth of mice, but had no influence on the progression of lung cancer in this model.
引用
收藏
页码：350 / 353
页数：4
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