CYSTEINE STRING PROTEINS - A POTENTIAL LINK BETWEEN SYNAPTIC VESICLES AND PRESYNAPTIC CA2+ CHANNELS

被引：164

作者：

MASTROGIACOMO, A

PARSONS, SM

ZAMPIGHI, GA

JENDEN, DJ

UMBACH, JA

GUNDERSEN, CB

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, DEPT MOLEC & MED PHARMACOL, LOS ANGELES, CA 90024 USA

[2] UNIV CALIF LOS ANGELES, SCH MED, DEPT ANAT & CELL BIOL, LOS ANGELES, CA 90024 USA

[3] UNIV CALIF SANTA BARBARA, DEPT CHEM, SANTA BARBARA, CA 93106 USA

来源：

SCIENCE | 1994年 / 263卷 / 5149期

关键词：

D O I：

10.1126/science.7906056

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Presynaptic calcium channels are key regulators of neurotransmitter release. Oocyte expression studies suggest that cysteine string proteins are essential subunits or modulators of these channels. Subcellular fractionation revealed that cysteine string proteins copurify with synaptic vesicles. An average vesicle had eight protein monomers with both the amino and carboxyl termini detected on the cytoplasmic face. Thus, docked synaptic vesicles may regulate presynaptic calcium channels and neurotransmitter release.

引用

页码：981 / 982

页数：2

共 28 条

[1] STOICHIOMETRIES OF ACETYLCHOLINE UPTAKE, RELEASE, AND DRUG-INHIBITION IN TORPEDO SYNAPTIC VESICLES - HETEROGENEITY IN ACETYLCHOLINE TRANSPORT AND STORAGE [J].