HIGH-RESOLUTION MAPPING OF D16LED-1, GART, GAS-4, CBR, PCP-4, AND ERG ON DISTAL MOUSE CHROMOSOME-16

被引：28

作者：

MJAATVEDT, AE ^{[1
]}

CITRON, MP ^{[1
]}

REEVES, RH ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, SCH MED,DEPT PHYSIOL,DEV GENET LAB,725 N WOLFE ST, BALTIMORE, MD 21205 USA

来源：

GENOMICS | 1993年 / 17卷 / 02期

关键词：

D O I：

10.1006/geno.1993.1336

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

More than 500 backcross progeny from four intersubspecific backcrosses were typed for six markers on distal mouse chromosome 16. Five of these represented genes that mapped within the Sod-1 to Ets-2 interval, which was shown previously to contain the weaver (wv) gene. The map order, including previously mapped reference markers, is (cen)-D16H21S16-D16Led-1-App-Sod-1-Gart-Gas-4-Cbr-wv-Pcp-4-Erg-Ets-2. This gene order recapitulates the order of the genes on human chromosome 21 where known. Two of these markers further define the region containing the weaver gene to a 3.9-cM segment between Cbr and Pcp-4. In addition, Pcp-4 was localized to human chromosome 21 by the presence of a human-specific restriction fragment in WAV-17, a mouse-human somatic cell hybrid with human chromosome 21 as the only human contribution. © 1993 Academic Press. All rights reserved.

引用

页码：382 / 386

页数：5

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