EFFECT OF PARENTERAL TESTOSTERONE THERAPY ON PENILE DEVELOPMENT IN BOYS WITH HYPOSPADIAS

被引：26

作者：

DAVITS, RJAM

VANDENAKER, ESS

SCHOLTMEIJER, RJ

KEIZERSCHRAMA, SMPFD

NIJMAN, RJM

机构：

[1] ERASMUS UNIV ROTTERDAM,SOPHIA CHILDRENS HOSP,DEPT PAEDIAT UROL,3000 DR ROTTERDAM,NETHERLANDS

[2] ERASMUS UNIV ROTTERDAM,SOPHIA CHILDRENS HOSP,DEPT ENDOCRINOL,3000 DR ROTTERDAM,NETHERLANDS

来源：

BRITISH JOURNAL OF UROLOGY | 1993年 / 71卷 / 05期

关键词：

D O I：

10.1111/j.1464-410X.1993.tb16031.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Forty boys with hypospadias received 2 mg/kg testosterone esters intramuscularly 5 and 2 weeks before surgical correction of the hypospadias. The effects on penile development were determined 3 and 5 weeks after the first injection and 3 and 12 months post-operatively. A significant effect on penile development was shown. This effect disappeared during the first year following treatment. There was no effect on bone maturation, children's height and the ultimate testosterone level. All adverse effects disappeared after cessation of therapy. Androgen receptor deficiency as a possible cause of hypospadias is not supported by our observations.

引用

页码：593 / 595

页数：3

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