INHIBITION OF ZN-2+-DEPENDENT ATPASE IN PROSTASOME MEMBRANE BY NONSATURATED, LONG-CHAIN FATTY-ACIDS

被引：3

作者：

RONQUIST, G

FRITHZ, G

机构：

[1] Department of Clinical Chemistry, University Hospital, Uppsala

[2] Department of Internal Medicine, Central Hospital, Eskilstuna

来源：

UROLOGIA INTERNATIONALIS | 1992年 / 48卷 / 02期

关键词：

ZN-2+-ATPASE INHIBITION; NONSATURATED FATTY ACIDS; PROSTASOMES;

D O I：

10.1159/000282327

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Arachidonic and oleic acids, opposite to stearic and palmitic acids, at concentrations near 10(-5) mol/l markedly inhibited Zn2+-dependent ATPase in human prostasome membranes. Arachidonic acid was somewhat more potent as inhibitor than oleic acid and the involvement of the metabolites of arachidonic acid cascade was less probable. Deoxycholate, an anionic biological detergent, produced a similar inhibitory effect although at a much higher concentration. The restraining role of nonsaturated, long-chain fatty acids on sperm motility in human semen is discussed in terms of their established inhibitory action on prostasome ATPase systems.

引用

页码：184 / 186

页数：3

共 12 条

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