BREAST-CANCER AND OTHER CANCERS IN NORWEGIAN FAMILIES WITH ATAXIA-TELANGIECTASIA

被引：117

作者：

BORRESEN, AL

ANDERSEN, TI

TRETLI, S

HEIBERG, A

MOLLER, P

机构：

[1] NORWEGIAN CANC REGISTRY,SIGGERUD,NORWAY

[2] NORWEGIAN RADIUM HOSP,SIGGERUD,NORWAY

[3] FRAMBU HLTH CTR,SIGGERUD,NORWAY

来源：

GENES CHROMOSOMES & CANCER | 1990年 / 2卷 / 04期

关键词：

D O I：

10.1002/gcc.2870020412

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients who are homozygous for ataxia‐telangiectasia (AT) have an exceptionally high incidence of cancer. Heterozygous individuals for the disease have been reported to be at an increased risk of cancer, particularly breast cancer in female carriers. We have analyzed eight Norwegian families with AT for cancer incidence in the parents, in the parents' sibs, grandparents, and grandparents' sibs. Two of the obligate heterozygote females have had premenopausal breast cancer. This incidence is significantly higher than expected for that group. No increase in the cancer incidence was observed in the parents' sibs, the grandparents, or the grandparents' sibs. Since the incidence of AT is low, data from many sources have to be combined to allow any conclusion. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：339 / 340

页数：2

共 11 条

[1]

BODER E, 1985, ATAXIA TELANGIECTASI, P1

[2] RELATIVE INCREASE OF T-CELLS EXPRESSING THE GAMMA-DELTA RATHER THAN THE ALPHA-BETA RECEPTOR IN ATAXIA TELANGIECTASIA [J].

CARBONARI, M ;

CHERCHI, M ;

PAGANELLI, R ;

GIANNINI, G ;

GALLI, E ;

GAETANO, C ;

PAPETTI, C ;

FIORILLI, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (02) :73-76

[3] LOCALIZATION OF AN ATAXIA-TELANGIECTASIA GENE TO CHROMOSOME 11Q22-23 [J].

GATTI, RA ;

BERKEL, I ;

BODER, E ;

BRAEDT, G ;

CHARMLEY, P ;

CONCANNON, P ;

ERSOY, F ;

FOROUD, T ;

JASPERS, NGJ ;

LANGE, K ;

LATHROP, GM ;

LEPPERT, M ;

NAKAMURA, Y ;

OCONNELL, P ;

PATERSON, M ;

SALSER, W ;

SANAL, O ;

SILVER, J ;

SPARKES, RS ;

SUSI, E ;

WEEKS, DE ;

WEI, S ;

WHITE, R ;

YODER, F .

NATURE, 1988, 336 (6199) :577-580

[4]

HANAWALT P, 1985, ATAXIA TELANGIECTASI, P67

[5]

LEHMANN AR, 1989, CANCER RES, V49, P6162

[6]

MORRELL D, 1986, J NATL CANCER I, V77, P89

[7]

PAINTER RB, 1985, ATAXIA TELANGIECTASI, P89

[8]

PIPPARD EC, 1988, CANCER RES, V48, P2929

[9] CANCER PREDISPOSITION OF ATAXIA-TELANGIECTASIA HETEROZYGOTES [J].

SWIFT, M ;

CHASE, CL ;

MORRELL, D .

CANCER GENETICS AND CYTOGENETICS, 1990, 46 (01) :21-27

[10] BREAST AND OTHER CANCERS IN FAMILIES WITH ATAXIA-TELANGIECTASIA [J].

SWIFT, M ;

REITNAUER, PJ ;

MORRELL, D ;

CHASE, CL .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (21) :1289-1294

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