NONVIRAL GENE-THERAPY

被引：40

作者：

TRECO, DA

SELDEN, RF

机构：

[1] TKT Incorporated, Cambridge, MA 02139

来源：

MOLECULAR MEDICINE TODAY | 1995年 / 1卷 / 07期

关键词：

D O I：

10.1016/S1357-4310(95)80030-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene therapy is a medical/surgical intervention currently being developed, in which genes are introduced into cells in order to treat or cure a wide variety of human diseases, The field has evolved over the past four decades, with most experimental gene-therapy studies based on the use of viruses to deliver the genes of therapeutic interest, More recently, a large number of non-viral approaches to gene therapy have emerged, yielding promising pre-clinical results, and which are currently being evaluated in early stage clinical trials.

引用

收藏

页码：314 / 321

页数：8

相关论文

共 39 条

[1] NONINVASIVE LIPOSOME-MEDIATED GENE DELIVERY CAN CORRECT THE ION-TRANSPORT DEFECT IN CYSTIC-FIBROSIS MUTANT MICE [J].

ALTON, EWFW ;

MIDDLETON, PG ;

CAPLEN, NJ ;

SMITH, SN ;

STEEL, DM ;

MUNKONGE, FM ;

JEFFERY, PK ;

GEDDES, DM ;

HART, SL ;

WILLIAMSON, R ;

FASOLD, KI ;

MILLER, AD ;

DICKINSON, P ;

STEVENSON, BJ ;

MCLACHLAN, G ;

DORIN, JR ;

PORTEOUS, DJ .

NATURE GENETICS, 1993, 5 (02) :135-142

[2]

BALTIMORE D, 1970, NATURE, V226, P1029

[3]

BRIGHAM KL, 1989, AM J MED SCI, V296, P278

[4] NO LUNG TOXICITY AFTER REPEATED AEROSOL OR INTRAVENOUS DELIVERY OF PLASMID-CATIONIC LIPOSOME COMPLEXES [J].

CANONICO, AE ;

PLITMAN, JD ;

CONARY, JT ;

MEYRICK, BO ;

BRIGHAM, KL .

JOURNAL OF APPLIED PHYSIOLOGY, 1994, 77 (01) :415-419

[5] INVIVO PROMOTER ACTIVITY AND TRANSGENE EXPRESSION IN MAMMALIAN SOMATIC TISSUES EVALUATED BY USING PARTICLE BOMBARDMENT [J].

CHENG, L ;

ZIEGELHOFFER, PR ;

YANG, NS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) :4455-4459

[6]

CLINE M, 1986, SCHWEIZ MED WOCHENSC, V116, P1459

[7] GENE-TRANSFER IN INTACT ANIMALS [J].

CLINE, MJ ;

STANG, H ;

MERCOLA, K ;

MORSE, L ;

RUPRECHT, R ;

BROWNE, J ;

SALSER, W .

NATURE, 1980, 284 (5755) :422-425

[8] GENE-THERAPY - CURRENT STATUS [J].

CLINE, MJ .

AMERICAN JOURNAL OF MEDICINE, 1987, 83 (02) :291-297

[9] DIRECT GENE-TRANSFER INTO MUSCLE [J].

DANKO, I ;

WOLFF, JA .

VACCINE, 1994, 12 (16) :1499-1502

[10] DIRECT TRANSFECTION OF VIRAL AND PLASMID DNA INTO THE LIVER OR SPLEEN OF MICE [J].

DUBENSKY, TW ;

CAMPBELL, BA ;

VILLARREAL, LP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (23) :7529-7533

← 1 2 3 4 →