THE INDIVIDUAL AND COMBINED TOXICITY OF KOJIC ACID AND AFLATOXIN IN BROILER-CHICKENS

被引：14

作者：

GIROIR, LE ^{[1
]}

HUFF, WE ^{[1
]}

KUBENA, LF ^{[1
]}

HARVEY, RB ^{[1
]}

ELISSALDE, MH ^{[1
]}

WITZEL, DA ^{[1
]}

YERSIN, AG ^{[1
]}

IVIE, GW ^{[1
]}

机构：

[1] USDA ARS,FOOD ANIM PROTECT RES LAB,ROUTE 5,BOX 810,COLLEGE STN,TX 77845

来源：

POULTRY SCIENCE | 1991年 / 70卷 / 06期

关键词：

KOJIC ACID; AFLATOXIN; TOXICITY; BODY WEIGHT; BROILERS;

D O I：

10.3382/ps.0701351

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The individual and combined effects of kojic acid and aflatoxin were studied in male broiler chicks (Peterson x Hubbard). The experiment had a two by two factorial arrangement of treatments with dietary treatments of 0 and 2,500 mg kojic acid/kg feed and 0 and 2.5 mg aflatoxin/kg feed. The broilers were obtained at 1 day of age and housed in electrically heated batteries with feed and water available for ad libitum intake until they reached 3 wk of age. The toxicity of kojic acid was characterized by significant (P < .05) reductions in body weight, the relative weight of the bursa of Fabricius, serum cholesterol concentration, and serum alkaline phosphatase activity, and by significant (P < .05) increases in the relative weight of the pancreas, proventriculus, and gizzard, and serum concentrations of uric acid and triglycerides. Aflatoxicosis was characterized by significant (P < .05) reductions in body weight, serum concentrations of total protein, albumin, cholesterol, and inorganic phosphorus, serum glutamic oxalacetic transaminase activity, and mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. Significant (P < .05) increases in the relative weight of the liver, kidney, spleen, pancreas, proventriculus, and heart, and the serum pyruvic transaminase activity were also caused by aflatoxin alone. The only significant (P < .05) interaction between kojic acid and aflatoxin, which can best be described as antagonistic, was seen through an increase in mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration. These data indicate that kojic acid is not an aflatoxin synergist at the levels used in the present study.

引用

页码：1351 / 1356

页数：6

共 16 条

[1]

CIEGLER A, 1971, MICROBIAL TOXINS, V6, P236

[2]

COLE RJ, 1981, HDB TOXIC FUNGAL MET, P759

[3] IMPAIRMENT OF COAGULATION FUNCTION DURING AFLATOXICOSIS IN YOUNG CHICKENS [J].

DOERR, JA ;

WYATT, RD ;

HAMILTON, PB .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1976, 35 (03) :437-446

[4] INVESTIGATION AND STANDARDIZATION OF PROTHROMBIN TIMES IN CHICKENS [J].

DOERR, JA ;

WYATT, RD ;

HAMILTON, PB .

POULTRY SCIENCE, 1975, 54 (04) :969-980

[5] TOXICOLOGICAL AND BIOCHEMICAL INTERACTIONS OF THE FUNGAL METABOLITES FUSARIC ACID AND KOJIC ACID WITH XENOBIOTICS IN HELIOTHIS-ZEA (F) AND SPODOPTERA-FRUGIPERDA (SMITH,J.E.) [J].

DOWD, PF .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1988, 32 (02) :123-134

[6]

DOWD PF, 1988, ENTOMOL EXP APPL, V47, P69, DOI 10.1007/BF00186717

[7] MULTIPLE RANGE AND MULTIPLE F TESTS [J].

DUNCAN, DB .

BIOMETRICS, 1955, 11 (01) :1-42

[8] TOXIC EFFECTS OF KOJIC ACID IN THE DIET OF MALE BROILERS [J].

GIROIR, LE ;

HUFF, WE ;

KUBENA, LE ;

HARVEY, RB ;

ELISSALDE, MH ;

WITZEL, DA ;

YERSIN, AG ;

IVIE, GW .

POULTRY SCIENCE, 1991, 70 (03) :499-503

[9]

HODGSON E, 1987, TXB MODERN TOXICOLOG, P65

[10] SYNERGISM BETWEEN AFLATOXIN AND OCHRATOXIN-A IN BROILER-CHICKENS [J].

HUFF, WE ;

DOERR, JA .

POULTRY SCIENCE, 1981, 60 (03) :550-555

← 1 2 →