HORMONE REPLACEMENT THERAPY PREVENTS CORONARY-ARTERY DISEASE IN OVARIECTOMIZED CHOLESTEROL-FED RABBITS

被引:23
作者
HAARBO, J [1 ]
HANSEN, BF [1 ]
CHRISTIANSEN, C [1 ]
机构
[1] KOMMUNE HOSP COPENHAGEN,BARTHOLIN INST,COPENHAGEN,DENMARK
关键词
ESTROGEN; PROGESTOGEN; CORONARY ARTERY DISEASE; CHOLESTEROL-FED RABBITS;
D O I
10.1111/j.1699-0463.1991.tb01250.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The prevention of coronary artery disease in women is of considerable importance. We have therefore investigated the influence of oestrogen monotherapy and oestrogen-progestogen replacement therapy on coronary artery disease using a simple morphometric method. We studied sixty-three cholesterolfed rabbits for nineteen weeks. They were randomized to either ovariectomy (51 rabbits) or a sham operation (12 rabbits). The ovariectomized rabbits were randomized to receive either 17-beta-estradiol, 17-beta-estradiol plus norethisterone acetate, 17-beta-estradiol plus levonorgestrel, or placebo. The rabbits with the sham operation received placebo. The hormone therapies reduced the development of coronary artery disease compared to placebo (p < 0.0001). Furthermore, the coronary artery disease was attended by atherosclerosis in the more distal parts of the coronary arteries (p < 0.0001), the thoracic aorta (p < 0.0001) and the abdominal aorta (p < 0.0001), and by a reduced relative heart weight (p < 0.05). We conclude that coronary atherosclerosis can be determined quantitatively by morphometry in rabbit arteries. Estradiol monotherapy reduces coronary atherosclerosis in cholesterol-fed rabbits and the addition of norethisterone acetate or levonorgestrel does not attenuate this beneficial effect.
引用
收藏
页码:721 / 727
页数:7
相关论文
共 17 条
  • [1] NONCONTRACEPTIVE ESTROGEN USE AND CARDIOVASCULAR-DISEASE
    BUSH, TL
    BARRETTCONNOR, E
    [J]. EPIDEMIOLOGIC REVIEWS, 1985, 7 : 80 - 104
  • [2] BUSH TL, 1988, CLIN CHEM, V34, pB60
  • [3] CARDIOVASCULAR MORTALITY AND NONCONTRACEPTIVE USE OF ESTROGEN IN WOMEN - RESULTS FROM THE LIPID RESEARCH CLINICS PROGRAM FOLLOW-UP-STUDY
    BUSH, TL
    BARRETTCONNOR, E
    COWAN, LD
    CRIQUI, MH
    WALLACE, RB
    SUCHINDRAN, CM
    TYROLER, HA
    RIFKIND, BM
    [J]. CIRCULATION, 1987, 75 (06) : 1102 - 1109
  • [4] MENOPAUSE AND THE RISK OF CORONARY HEART-DISEASE IN WOMEN
    COLDITZ, GA
    WILLETT, WC
    STAMPFER, MJ
    ROSNER, B
    SPEIZER, FE
    HENNEKENS, CH
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (18) : 1105 - 1110
  • [5] L-NORGESTREL AND PROGESTERONE HAVE DIFFERENT INFLUENCES ON PLASMA-LIPOPROTEINS
    FAHRAEUS, L
    LARSSONCOHN, U
    WALLENTIN, L
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1983, 13 (06) : 447 - 453
  • [6] FOLCH J, 1957, J BIOL CHEM, V226, P497
  • [7] SOME NEW, SIMPLE AND EFFICIENT STEREOLOGICAL METHODS AND THEIR USE IN PATHOLOGICAL RESEARCH AND DIAGNOSIS - REVIEW ARTICLE
    GUNDERSEN, HJG
    BENDTSEN, TF
    KORBO, L
    MARCUSSEN, N
    MOLLER, A
    NIELSEN, K
    NYENGAARD, JR
    PAKKENBERG, B
    SORENSEN, FB
    VESTERBY, A
    WEST, MJ
    [J]. APMIS, 1988, 96 (05) : 379 - 394
  • [8] ESTROGEN MONOTHERAPY AND COMBINED ESTROGEN-PROGESTOGEN REPLACEMENT THERAPY ATTENUATE AORTIC ACCUMULATION OF CHOLESTEROL IN OVARIECTOMIZED CHOLESTEROL-FED RABBITS
    HAARBO, J
    LETHESPENSEN, P
    STENDER, S
    CHRISTIANSEN, C
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (04) : 1274 - 1279
  • [9] EFFECTS OF DIFFERENT PROGESTOGENS ON LIPOPROTEINS DURING POST-MENOPAUSAL REPLACEMENT THERAPY
    HIRVONEN, E
    MALKONEN, M
    MANNINEN, V
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1981, 304 (10) : 560 - 563
  • [10] KAPLAN HM, 1979, RABBIT MODEL PRINCIP, P127