EFFECTS OF POTASSIUM CHANNEL BLOCKERS ON BACLOFEN-INDUCED SUPPRESSION OF PAROXYSMAL DISCHARGES IN RAT NEOCORTICAL SLICES

被引：15
作者：
ONG, J [1 ]
KERR, DIB [1 ]
JOHNSTON, GAR [1 ]
机构：
[1] UNIV SYDNEY,DEPT PHARMACOL,SYDNEY,NSW 2006,AUSTRALIA
来源：
NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期
基金：
英国医学研究理事会;
关键词：
Baclofen; Mg-free medium; Paroxysmal discharge; Potassium channel blocker; Rat neocortex;
D O I：
10.1016/0304-3940(90)90206-O
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Baclofen reduced the frequency and aborted the bursts of spontaneous paroxysmal discharges in rat neocortical slices maintained in magnesium-free medium. This action was prevented by pretreatment with barium or caesium, which each increased the ictaform burst frequency, amplitude and duration. 4-Aminopyridine also increased the burst frequency but reduced the amplitude and did not completely prevent the action of baclofen. Evidently baclofen suppresses such discharges by opening potassium channels normally involved in limiting the burst activity. © 1990.
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收藏
页码：216 / 222
页数：7
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