INHIBITION OF GROWTH BY THE ANTIHORMONE RU486 IN DIFFERENT HEPATOMA-CELL LINES

被引：4

作者：

CHASSEROTGOLAZ, S ^{[1
]}

BECK, G ^{[1
]}

VENETIANER, A ^{[1
]}

机构：

[1] BIOL RES CTR,INST GENET,H-6701 SZEGED,HUNGARY

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1991年 / 82卷 / 2-3期

基金：

匈牙利科学研究基金会;

关键词：

ANTIGLUCOCORTICOID; METABOLIZATION; ANTIPROLIFERATIVE EFFECT; GLUCOCORTICOID RECEPTOR;

D O I：

10.1016/0303-7207(91)90026-O

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The synthetic steroid RU486 (17-beta-hydroxy-11-beta-(4-dimethylaminophenyl)-17-alpha-(1-propynyl)-estra-4,9-dien-3-one), which has been shown to display antiprogestin and antiglucocorticoid properties in different systems, exerts antiglucocorticoid effects and inhibits the cell growth in a concentration-dependent manner on Reuber rat hepatoma cell variants. This effect can be observed on glucocorticoid-sensitive cells, containing glucocorticoid receptors, and on glucocorticoid-resistant cells displaying a very low level of dexamethasone binding. Metabolization of RU486 occurs in different glucocorticoid-resistant hepatoma variants; these cells are less sensitive to the growth inhibitory effect of the antihormone than the steroid-sensitive cells which do not metabolize RU486. Thus, metabolization of RU486 must also be taken into account for the efficacy of this antagonist on cell growth.

引用

页码：151 / 158

页数：8

共 23 条

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