PHARMACOLOGICAL STUDIES ON THE TXA2 SYNTHETASE INHIBITOR (E)-3-[P-(1H-IMIDAZOL-1-YLMETHYL)PHENYL]-2-PROPENOIC ACID (OKY-046)

被引：74

作者：

HIRAKU, S ^{[1
]}

TANIGUCHI, K ^{[1
]}

WAKITANI, K ^{[1
]}

OMAWARI, N ^{[1
]}

KIRA, H ^{[1
]}

MIYAMOTO, T ^{[1
]}

OKEGAWA, T ^{[1
]}

KAWASAKI, A ^{[1
]}

UJIIE, A ^{[1
]}

机构：

[1] KISSEI PHARMACEUT CO LTD,CENT RES LABS,MATSUMOTO 399,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1986年 / 41卷 / 03期

关键词：

D O I：

10.1254/jjp.41.393

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：393 / 401

页数：9

共 23 条

[1]

BROUGHTONSMITH NK, 1983, GUT, V24, P1176

[2] INHIBITION OF PLATELET THROMBOXANE-A2 SYNTHASE ACTIVITY BY SODIUM 5-(3'-PYRIDINYLMETHYL)BENZOFURAN-2-CARBOXYLATE [J].

GORMAN, RR ;

JOHNSON, RA ;

SPILMAN, CH ;

AIKEN, JW .

PROSTAGLANDINS, 1983, 26 (02) :325-342

[3] PURIFICATION OF THROMBOXANE SYNTHETASE AND EVIDENCE OF 2 DISTINCT MECHANISMS FOR THE FORMATION OF 12-L-HYDROXY-5,8,10-HEPTADECATRIENOIC ACID BY PORCINE LUNG MICROSOMES [J].

HALL, ER ;

TAI, HH .

BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 665 (03) :498-503

[4] THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES [J].

HAMBERG, M ;

SVENSSON, J ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :2994-2998

[5] RESOLUTION OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE AND THROMBOXANE SYNTHASE OF HUMAN PLATELETS - (SUBCELLULAR DISTRIBUTION-12L-HYDROPEROXY-5,8,10,14-EICOSATETRAENOIC ACID TRITON X-100 DEAE-CELLULOSE) [J].

HAMMARSTROM, S ;

FALARDEAU, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) :3691-3695

[6] ARACHIDONIC-ACID METABOLIC PATHWAYS IN THE RABBIT PERICARDIUM [J].

HONDA, A ;

MORRISON, AR ;

MCCLUSKEY, ER ;

NEEDLEMAN, P .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 794 (03) :403-410

[7]

KATSURA M, 1983, ADV PROSTAG THROMB L, V11, P351

[8] EFFECT OF THROMBOXANE SYNTHETASE INHIBITORS (OKY-046,OKY-1580) ON THE ACTION OF BRONCHOACTIVE AGENTS IN GUINEA-PIG TRACHEAL STRIPS AND ON ARACHIDONATE METABOLISM IN GUINEA-PIG LUNG LOBES [J].

KITAMURA, S ;

ISHIHARA, Y ;

TAKAKU, F .

PROSTAGLANDINS LEUKOTRIENES AND MEDICINE, 1984, 14 (03) :341-350

[9] CHARACTERIZATION OF IMIDAZO[1,5-A]PYRIDINE-5-HEXANOIC ACID (CGS-13080) AS A SELECTIVE THROMBOXANE SYNTHETASE INHIBITOR USING INVITRO AND INVIVO BIOCHEMICAL-MODELS [J].

KU, EC ;

MCPHERSON, SE ;

SIGNOR, C ;

CHERTOCK, H ;

CASH, WD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 112 (03) :899-906

[10]

LEBRETON GC, 1979, P NATL ACAD SCI USA, V76, P4097

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