Molecular and functional characterization of a rat brain K-v beta 3 potassium channel subunit

被引：95

作者：

Heinemann, SH ^{[1
]}

Rettig, J ^{[1
]}

Wunder, F ^{[1
]}

Pongs, O ^{[1
]}

机构：

[1] INST NEURALE SIGNALVERARBEITUNG,ZENTRUM MOLEK NEUROBIOL HAMBURG,D-20246 HAMBURG,GERMANY

来源：

FEBS LETTERS | 1995年 / 377卷 / 03期

关键词：

potassium channel; channel inactivation; beta subunit; gene family; rat brain;

D O I：

10.1016/0014-5793(95)01377-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel potassium channel beta-subunit (K-v beta 3) was cloned from rat brain being the third member of a K-v beta subunit gene family. It is a protein of 403 amino acid residues with a 68% amino acid sequence homology to K-v beta 1.1, K-v beta 3 is primarily expressed in rat brain having a distribution distinct to those of K-v beta 1.1 and K-v beta 2. This subunit also has a long N-terminal structure and induces inactivation in N-terminal deleted K(v)1.4 but not in other members of the K(v)1 channel family. Similarly to K-v beta 1.1, the K-v beta 3-induced inactivation is regulated by the intracellular redox potential.

引用

页码：383 / 389

页数：7

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