INCREASE IN THE CALCIUM LEVEL FOLLOWING ANODAL POLARIZATION IN THE RAT-BRAIN

被引:122
作者
ISLAM, N
AFTABUDDIN, M
MORIWAKI, A
HATTORI, Y
HORI, Y
机构
[1] Department of Physiology, Okayama University Medical School, Okayama, 700
关键词
DIRECT CURRENT; RAT; BRAIN; SENSORIMOTOR CORTEX; DARK NEURON; CA-45; AUTORADIOGRAPHY; ANODAL POLARIZATION;
D O I
10.1016/0006-8993(95)00434-R
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The accumulation of calcium ions (Ca) was examined in the rat brain by means of Ca-45 autoradiography following the application of a weak anodal direct current to the surface of the sensorimotor cortex. Repetition of the anodal polarization with 3.0 mu A for 30 min caused more Ca to accumulate in the cerebral cortex. The degree and extent of accumulation was greater in the hemisphere ipsilateral to the polarization than in the other. Accumulation was also noted in the hippocampus and thalamus. Ca accumulation was detected after 24 h and it remained virtually constant up to 72 h after the last polarization. The results suggest that a long-lasting disturbance of Ca homeostasis is involved in the cortical plastic changes seen following anodal polarization.
引用
收藏
页码:206 / 208
页数:3
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