EXCITOTOXICITY AND CHOLINERGIC CHEMICAL MARKERS DURING PROGRAMMED MOTOR-NEURON DEATH

被引：2

作者：

RODRIGUEZITHURRALDE, D

VINCENT, O

机构：

[1] Division of Neuromyology, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), C. Postal 11600 Montevideo

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1994年 / 124卷

关键词：

ACETYLCHOLINESTERASE; DEVELOPMENT; EXCITOTOXICITY; GLUTAMATE; MOTOR NEURON; SPINAL CORD; SELECTIVE VULNERABILITY;

D O I：

10.1016/0022-510X(94)90176-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We measured cholinergic markers and acetylcholinesterase (AChE) molecular forms after glutamate receptor stimulation of superfused slices of mouse spinal cord at different developmental ages. AChE globular forms were secreted in a dose-dependent fashion. A period of selective sensitivity to excitotoxic agents was detected by increased acetylcholine (ACh) release and AChE secretion (sAChE) at postnatal day 14. Strychnine-resistant glycine stimulation potentiated glutamate-induced AChE release, suggesting N-methyl-D-aspartate (NMDA) receptor involvement.

引用

页码：52 / 53

页数：2

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