2-PHENYL ISOPROPYL ESTERS AS CARBOXYL TERMINUS PROTECTING GROUPS IN THE FAST SYNTHESIS OF PEPTIDE-FRAGMENTS

被引：49

作者：

YUE, CW ^{[1
]}

THIERRY, J ^{[1
]}

POTIER, P ^{[1
]}

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 02期

关键词：

AMINO-ACIDS; ESTERIFICATION; PEPTIDE SYNTHESIS;

D O I：

10.1016/S0040-4039(00)60578-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a Fmoc strategy is used to build up peptide fragments.

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页码：323 / 326

页数：4

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