DIFFERENTIAL-EFFECTS OF CROMAKALIM ON PANCREATIC VASCULAR-RESISTANCE AND INSULIN-SECRETION INVITRO

被引:7
|
作者
PETIT, P [1 ]
HILLAIREBUYS, D [1 ]
MIR, AK [1 ]
LOUBATIERESMARIANI, MM [1 ]
机构
[1] SANDOZ LTD,PRECLIN RES,CH-4002 BASEL,SWITZERLAND
关键词
CROMAKALIM; K+ CHANNEL; INSULIN SECRETION; PANCREATIC VESSEL;
D O I
10.1111/j.1472-8206.1992.tb00110.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of the potassium channel opener cromakalim on vascular resistance and insulin output were investigated in vitro within the same experimental preparation, the isolated rat pancreas perfused at a constant pressure with a physiological solution containing 8.3 mM glucose. Cromakalim induced a clear and concentration-dependent dilatory response of pancreatic vessels; the concentration-response curve obtained in the range of 10(-8)-10(-5) M had a sigmoidal shape with a linear part between 10(-7) and 10(-6) M. Cromakalim did not inhibit insulin release at these concentrations. These results differ from those obtained with diazoxide, which has been previously shown both to inhibit insulin secretion and induce vasodilatation of the pancreatic vascular bed in a similar range of concentrations (10(-6) - 10(-5) M). The data presented provide evidence for a selective effect of cromakalim on pancreatic vascular resistance. Our present and previous results support the view that cromakalim is effective on K+ channels of vascular smooth muscle that differ from the ATP-sensitive K+ channel opened by diazoxide in insulin-secreting B-cells.
引用
收藏
页码:185 / 190
页数:6
相关论文
共 50 条
  • [31] PANCREATIC INSULIN-SECRETION IN EXOCRINE PANCREATIC-CANCER
    BELL, RH
    PLACE, S
    MCCULLOUGH, P
    RAY, MB
    ROGERS, DH
    JOURNAL OF SURGICAL RESEARCH, 1986, 40 (06) : 588 - 596
  • [32] EFFECTS OF TEMPERATURE AND GLUCOSE ON INSULIN-SECRETION INVITRO OF PANCREAS OF HEDGEHOG AND RAT
    HOOPARIS, R
    AINA, E
    SUTTER, BCJ
    JOURNAL DE PHYSIOLOGIE, 1979, 75 (05): : A29 - A29
  • [33] EFFECTS OF BORDETELLA-PERTUSSIS EXTRACT ON INSULIN-SECRETION INVIVO AND INVITRO
    SUN, AM
    MACMORINE, HG
    CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE, 1979, 70 (01): : 62 - 62
  • [34] EFFECTS OF SUPERIOR CERVICAL GANGLIONECTOMY ON INSULIN-SECRETION BY MOUSE PANCREAS INVITRO
    GARCIA, JB
    ROMEO, HE
    BASABE, JC
    CARDINALI, DP
    MEDICINA-BUENOS AIRES, 1987, 47 (06) : 582 - 583
  • [35] EFFECT OF CYCLOSPORIN-A ON INSULIN-SECRETION INVITRO
    LAUBE, F
    HAHN, HJ
    HORMONE AND METABOLIC RESEARCH, 1985, 17 (01) : 43 - 44
  • [36] EFFECT OF EXOGENOUS ZINC ON INSULIN-SECRETION INVITRO
    FIGLEWICZ, DP
    HELDT, A
    FORHAN, SE
    GRODSKY, GM
    ENDOCRINOLOGY, 1981, 108 (02) : 730 - 732
  • [37] INHIBITION OF INVITRO ISLET INSULIN-SECRETION BY AZATHIOPRINE
    VIVIANI, GL
    BORGOGLIO, MG
    FONTANA, I
    LEPRINI, A
    VALENTE, U
    ADEZATI, L
    DIABETES, 1989, 38 : 293 - 294
  • [38] EFFECT OF HEPARIN ON INSULIN-SECRETION INVIVO AND INVITRO
    OROSZ, L
    RESEARCH IN EXPERIMENTAL MEDICINE, 1976, 167 (03) : 239 - 254
  • [39] INSULIN DELIVERY FROM ARTIFICIAL DEVICE THROUGH DIFFUSION - INVITRO IMITATION OF PANCREATIC BASAL INSULIN-SECRETION
    DUTZ, W
    STEPHEN, RL
    BUHR, N
    WOLTANSKI, KP
    ARTIFICIAL ORGANS, 1987, 11 (04) : 314 - 314
  • [40] ALLOXAN INHIBITION OF LEUCINE METABOLISM AND INSULIN-SECRETION OF ISOLATED PANCREATIC-ISLETS INVITRO
    BORG, LAH
    ACTA ENDOCRINOLOGICA, 1980, 94 : 11 - 11