EARLY STAGES OF MOTOR-NEURON DIFFERENTIATION REVEALED BY EXPRESSION OF HOMEOBOX GENE ISLET-1

被引：578
作者：
ERICSON, J
THOR, S
EDLUND, T
JESSELL, TM
YAMADA, T
机构：
[1] COLUMBIA UNIV, HAMMER HLTH SCI CTR, CTR NEUROBIOL & BEHAV, HOWARD HUGHES MED INST, NEW YORK, NY 10032 USA
[2] UMEA UNIV, DEPT MICROBIOL, S-90187 UMEA, SWEDEN
来源：
SCIENCE | 1992年 / 256卷 / 5063期
关键词：
D O I：
10.1126/science.1350865
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Motor neurons in the embryonic chick spinal cord express a homeobox gene, islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.
引用
收藏
页码：1555 / 1560
页数：6
相关论文
共 39 条
[1]  
BLOCHGALLEGO E, 1991, DEVELOPMENT, V111, P221
[2]   THE LOCATION AND DISTRIBUTION OF NEURAL CREST-DERIVED SCHWANN-CELLS IN DEVELOPING PERIPHERAL-NERVES IN THE CHICK FORELIMB [J].
CARPENTER, EM ;
HOLLYDAY, M .
DEVELOPMENTAL BIOLOGY, 1992, 150 (01) :144-159
[3]   REGIONALLY RESTRICTED DEVELOPMENTAL DEFECTS RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.5 [J].
CHISAKA, O ;
CAPECCHI, MR .
NATURE, 1991, 350 (6318) :473-479
[4]   THE STRUCTURAL AND FUNCTIONAL-ORGANIZATION OF THE MURINE HOX GENE FAMILY RESEMBLES THAT OF DROSOPHILA HOMEOTIC GENES [J].
DUBOULE, D ;
DOLLE, P .
EMBO JOURNAL, 1989, 8 (05) :1497-1505
[5]   DETERMINATION OF PRIMARY MOTONEURON IDENTITY IN DEVELOPING ZEBRAFISH EMBRYOS [J].
EISEN, JS .
SCIENCE, 1991, 252 (5005) :569-572
[6]   SPLOTCH (SP2H), A MUTATION AFFECTING DEVELOPMENT OF THE MOUSE NEURAL-TUBE, SHOWS A DELETION WITHIN THE PAIRED HOMEODOMAIN OF PAX-3 [J].
EPSTEIN, DJ ;
VEKEMANS, M ;
GROS, P .
CELL, 1991, 67 (04) :767-774
[7]   EARLY EVENTS IN NEUROMUSCULAR-JUNCTION FORMATION INVITRO - INDUCTION OF ACETYLCHOLINE-RECEPTOR CLUSTERS IN THE POSTSYNAPTIC MEMBRANE AND MORPHOLOGY OF NEWLY FORMED SYNAPSES [J].
FRANK, E ;
FISCHBACH, GD .
JOURNAL OF CELL BIOLOGY, 1979, 83 (01) :143-158
[8]   NOVEL CYSTEINE-RICH MOTIF AND HOMEODOMAIN IN THE PRODUCT OF THE CAENORHABDITIS-ELEGANS CELL LINEAGE GENE LIN-II [J].
FREYD, G ;
KIM, SK ;
HORVITZ, HR .
NATURE, 1990, 344 (6269) :876-879
[9]   PAX-3, A NOVEL MURINE DNA-BINDING PROTEIN EXPRESSED DURING EARLY NEUROGENESIS [J].
GOULDING, MD ;
CHALEPAKIS, G ;
DEUTSCH, U ;
ERSELIUS, JR ;
GRUSS, P .
EMBO JOURNAL, 1991, 10 (05) :1135-1147
[10]   THE MURINE AND DROSOPHILA HOMEOBOX GENE COMPLEXES HAVE COMMON FEATURES OF ORGANIZATION AND EXPRESSION [J].
GRAHAM, A ;
PAPALOPULU, N ;
KRUMLAUF, R .
CELL, 1989, 57 (03) :367-378
1234