THE EFFECT OF PROLONGED EXPOSURE OF RATS TO SUBLETHAL DOSE OF ACETAMINOPHEN

被引：0
|
作者：
UDOSEN, EO
EBONG, PE
机构：
来源：
CENTRAL AFRICAN JOURNAL OF MEDICINE | 1991年 / 37卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this report, we studied the effect of sub-lethal doses (20mg, 30mg, 100mg, 200mg and 300mg/Kg body weight) and duration of acetaminophen given intraperitoneally (i.p) to male albino rats; on the level of pc methaemoglobin and some liver function tests: Alkaline phosphatase, free and conjugated bilirubin. The study showed that the increase in pc methaemoglobin, free and conjugated bilirubin in rats treated with acetaminophen are significantly (P < 0.05) greater than those for the control rats and that the measured parameters increase with acetaminophen concentrations. The results also show that the free bilirubin is probably displaced from plasma albumin.
引用
收藏
页码：126 / 129
页数：4
相关论文
共 50 条
  • [41] EFFECT OF TOLUENE INHALATION ON THE LIVER OF RATS - DEPENDENCE ON SEX DOSE AND EXPOSURE TIME
    UNGVARY, G
    MANYA, S
    TATRA, E
    SZEBERENY, S
    CSEH, RJ
    MOLNAR, J
    FOLLY, G
    JOURNAL OF HYGIENE EPIDEMIOLOGY MICROBIOLOGY AND IMMUNOLOGY, 1980, 24 (03): : 242 - &
  • [42] EFFECT OF DOSE RATE AND EXPOSURE FRACTIONATION ON PLASMA IRON KINETICS IN RATS AND MAN
    RICKS, RC
    EDWARDS, CL
    RADIATION RESEARCH, 1970, 43 (01) : 240 - &
  • [43] Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats
    Fu, Hui Qun
    Yang, Ting
    Xiao, Wei
    Fan, Long
    Wu, Yan
    Terrando, Niccolo
    Wang, Tian Long
    PLOS ONE, 2014, 9 (08):
  • [44] EFFECT OF LIFETIME LOW DOSE EXPOSURE TO CADMIUM ON LIPID METABOLISM OF WISTAR RATS
    Almasiova, Viera
    Lukacinova, Agnesa
    Holovska, Katarina
    Cigankova, Viera
    Nistiar, Frantisek
    JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES, 2012, 2 (01): : 293 - 303
  • [45] The application and limitations of exposure multiplication factors in sublethal effect modelling
    Sherborne, Neil
    Jager, Tjalling
    Goussen, Benoit
    Trijau, Marie
    Ashauer, Roman
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [46] EFFECT OF PROLONGED ADMINISTRATION OF HIGH DOSE OF TESTOSTERONE PROPIONATE ON THE ADRENAL CORTEX OF YOUNG MALE RATS
    ROY, SN
    KARKUN, JN
    MUKERJI, B
    ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, 1958, 116 (3-4): : 402 - 409
  • [47] The application and limitations of exposure multiplication factors in sublethal effect modelling
    Neil Sherborne
    Tjalling Jager
    Benoit Goussen
    Marie Trijau
    Roman Ashauer
    Scientific Reports, 12
  • [48] Avoidance Behaviour and Anxiety in Rats Irradiated with a Sublethal Dose of Gamma-Rays
    Lenka Tomášová
    B. Šmajda
    M. Bona
    Acta Biologica Hungarica, 2011, 62 : 341 - 348
  • [49] AVOIDANCE BEHAVIOUR AND ANXIETY IN RATS IRRADIATED WITH A SUBLETHAL DOSE OF GAMMA-RAYS
    Tomasova, Lenka
    Smajda, B.
    Bona, M.
    ACTA BIOLOGICA HUNGARICA, 2011, 62 (04): : 341 - 348
  • [50] Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats
    Herrington, Joshua A.
    Darwich, Janet Guss
    Harshaw, Christopher
    Brigande, Alev M.
    Leif, Erica B.
    Currie, Paul J.
    DEVELOPMENTAL PSYCHOBIOLOGY, 2022, 64 (03)
12345