THE EFFECT OF PROLONGED EXPOSURE OF RATS TO SUBLETHAL DOSE OF ACETAMINOPHEN

被引：0
|
作者：
UDOSEN, EO
EBONG, PE
机构：
来源：
CENTRAL AFRICAN JOURNAL OF MEDICINE | 1991年 / 37卷 / 04期
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R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this report, we studied the effect of sub-lethal doses (20mg, 30mg, 100mg, 200mg and 300mg/Kg body weight) and duration of acetaminophen given intraperitoneally (i.p) to male albino rats; on the level of pc methaemoglobin and some liver function tests: Alkaline phosphatase, free and conjugated bilirubin. The study showed that the increase in pc methaemoglobin, free and conjugated bilirubin in rats treated with acetaminophen are significantly (P < 0.05) greater than those for the control rats and that the measured parameters increase with acetaminophen concentrations. The results also show that the free bilirubin is probably displaced from plasma albumin.
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页码：126 / 129
页数：4
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