QUANTITATIVE GLC DETERMINATION OF OXYCODONE IN HUMAN-PLASMA

被引：9

作者：

RENZI, NL

TAM, JN

机构：

[1] Biochemical Research, McNeil Laboratories, Fort Washington, Pennsylvania

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 01期

关键词：

GLC—analysis; oxycodone in plasma; Narcotic analgesics—oxycodone; GLC analysis in plasma; Oxycodone—GLC analysis in plasma;

D O I：

10.1002/jps.2600680115

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A GLC assay was developed for the determination of oxycodone levels in human plasma using a nitrogen‐specific detector. The assay was developed for use in bioavailability studies of therapeutic doses of oxycodone. After ingestion of a commercial tablet containing 4.5 mg of oxycodone hydrochloride and 0.38 mg of oxycodone terephthalate by six volunteers, the mean peak oxycodone concentration in plasma was 18.4 ng/ml at 1 hr. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：43 / 45

页数：3

共 8 条

[1]

ADLER TK, 1955, J PHARMACOL EXP THER, V114, P251

[2] USE OF HUMAN FETAL ILEUM FOR EVALUATION OF SMOOTH MUSCLE EFFECTS OF NARCOTIC ANALGESICS [J].