A HIGHLY POTENT, ORALLY-ACTIVE IMIDAZO[4,5-B]PYRIDINE BIPHENYLACYLSULFONAMIDE (MK-996-L-159,282) - A NEW ANGIOTENSIN-II RECEPTOR ANTAGONIST

被引：59
作者：
CHAKRAVARTY, PK
NAYLOR, EM
CHEN, A
CHANG, RSL
CHEN, TB
FAUST, KA
LOTTI, VJ
KIVLIGHN, SD
GABLE, RA
ZINGARO, GJ
SCHORN, TW
SCHAFFER, LW
BROTEN, TP
SIEGL, PKS
PATCHETT, AA
GREENLEE, WJ
机构：
[1] MERCK SHARP & DOHME LTD,DEPT NEW LEAD PHARMACOL,W POINT,PA 19486
[2] MERCK SHARP & DOHME LTD,DEPT PHARMACOL,W POINT,PA 19486
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 24期
关键词：
D O I：
10.1021/jm00050a002
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：4068 / 4072
页数：5
相关论文
共 53 条
[11]   2 ANGIOTENSIN-II BINDING-SITES IN RAT-BRAIN REVEALED USING [I-125] SAR1, ILE8-ANGIOTENSIN-II AND SELECTIVE NONPEPTIDE ANTAGONISTS [J].
CHANG, RSL ;
LOTTI, VJ ;
CHEN, TB ;
FAUST, KA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 171 (02) :813-817
[12]  
CHANG RSL, 1992, J PHARMACOL EXP THER, V262, P133
[13]   IN-VITRO PHARMACOLOGY OF MK-996, A NEW POTENT AND SELECTIVE ANGIOTENSIN-II (AT(1)) RECEPTOR ANTAGONIST [J].
CHANG, RSL ;
BENDESKY, RJ ;
CHEN, TB ;
FAUST, KA ;
KLING, PJ ;
OMALLEY, SA ;
NAYLOR, EM ;
CHAKRAVARTY, PK ;
PATCHETT, AA ;
GREENLEE, WJ ;
CLINESCHMIDT, BV ;
LOTTI, VJ .
DRUG DEVELOPMENT RESEARCH, 1994, 32 (03) :161-171
[14]  
COLLETTI AE, 1994, DRUG METAB DISPOS, V22, P183
[15]  
DEGASPARO M, 1992, COLLOQ INSE, V222, P3
[16]   CONVENIENT PROCEDURE FOR THE PREPARATION OF ALKYL AND ARYL SUBSTITUTED N-(AMINOALKYLACYL)SULFONAMIDES [J].
DRUMMOND, JT ;
JOHNSON, G .
TETRAHEDRON LETTERS, 1988, 29 (14) :1653-1656
[17]   THE DISCOVERY OF DUP-753, A POTENT, ORALLY ACTIVE NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST [J].
DUNCIA, JV ;
CARINI, DJ ;
CHIU, AT ;
JOHNSON, AL ;
PRICE, WA ;
WONG, PC ;
WEXLER, RR ;
TIMMERMANS, PBMWM .
MEDICINAL RESEARCH REVIEWS, 1992, 12 (02) :149-191
[18]  
FERRARI B, 1993, BIOMED CHEM LETT, V3, P757
[19]  
Greenlee WJ, 1992, ANNU REP MED CHEM, V27, P59
[20]  
GRIENDLING KK, 1993, THROMB HAEMOSTASIS, V70, P188
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