A HIGHLY POTENT, ORALLY-ACTIVE IMIDAZO[4,5-B]PYRIDINE BIPHENYLACYLSULFONAMIDE (MK-996-L-159,282) - A NEW ANGIOTENSIN-II RECEPTOR ANTAGONIST

被引：58
作者：
CHAKRAVARTY, PK
NAYLOR, EM
CHEN, A
CHANG, RSL
CHEN, TB
FAUST, KA
LOTTI, VJ
KIVLIGHN, SD
GABLE, RA
ZINGARO, GJ
SCHORN, TW
SCHAFFER, LW
BROTEN, TP
SIEGL, PKS
PATCHETT, AA
GREENLEE, WJ
机构：
[1] MERCK SHARP & DOHME LTD,DEPT NEW LEAD PHARMACOL,W POINT,PA 19486
[2] MERCK SHARP & DOHME LTD,DEPT PHARMACOL,W POINT,PA 19486
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 24期
关键词：
D O I：
10.1021/jm00050a002
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：4068 / 4072
页数：5
相关论文
共 53 条
  • [1] BALDWIN JJ, 1994, EXPERT OPIN THER PAT, V4, P505
  • [2] ANGIOTENSIN-II RECEPTOR SUBTYPES - CHARACTERIZATION, SIGNALING MECHANISMS, AND POSSIBLE PHYSIOLOGICAL IMPLICATIONS
    BOTTARI, SP
    DEGASPARO, M
    STECKELINGS, UM
    LEVENS, NR
    [J]. FRONTIERS IN NEUROENDOCRINOLOGY, 1993, 14 (02) : 123 - 171
  • [3] BRILLA CG, 1992, CIRCULATION, V86, P89
  • [4] BUCHHOLZ RA, 1993, ANNU REP MED CHEM, V28, P69
  • [5] NOMENCLATURE FOR ANGIOTENSIN RECEPTORS - A REPORT OF THE NOMENCLATURE-COMMITTEE OF THE COUNCIL-FOR-HIGH-BLOOD-PRESSURE-RESEARCH
    BUMPUS, FM
    CATT, KJ
    CHIU, AT
    DEGASPARO, M
    GOODFRIEND, T
    HUSAIN, A
    PEACH, MJ
    TAYLOR, DG
    TIMMERMANS, PBMWM
    [J]. HYPERTENSION, 1991, 17 (05) : 720 - 721
  • [6] NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - THE DISCOVERY OF A SERIES OF N-(BIPHENYLYLMETHYL)IMIDAZOLES AS POTENT, ORALLY ACTIVE ANTIHYPERTENSIVES
    CARINI, DJ
    DUNCIA, JV
    ALDRICH, PE
    CHIU, AT
    JOHNSON, AL
    PIERCE, ME
    PRICE, WA
    SANTELLA, JB
    WELLS, GJ
    WEXLER, RR
    WONG, PC
    YOO, SE
    TIMMERMANS, PBMWM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) : 2525 - 2547
  • [7] Carretero O.A., 1981, ANGIOTENSIN CONVERTI, P105
  • [8] QUINAZOLINONE BIPHENYL ACYLSULFONAMIDES - A POTENT NEW CLASS OF ANGIOTENSIN-II RECEPTOR ANTAGONISTS
    CHAKRAVARTY, PK
    STRELITZ, RA
    CHEN, TB
    CHANG, RSL
    LOTTI, VJ
    ZINGARO, GJ
    SCHORN, TW
    KIVLIGHN, SD
    SIEGL, PKS
    PATCHETT, AA
    GREENLEE, WJ
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (01) : 75 - 80
  • [9] TRIAZOLINONES AS NONPEPTIDE ANGIOTENSIN-II ANTAGONISTS .2. DISCOVERY OF A POTENT AND ORALLY-ACTIVE TRIAZOLINONE ACYLSULFONAMIDE
    CHANG, LL
    ASHTON, WT
    FLANAGAN, KL
    NAYLOR, EM
    CHAKRAVARTY, PK
    PATCHETT, AA
    GREENLEE, WJ
    BENDESKY, RJ
    CHEN, TB
    FAUST, KA
    KLING, PJ
    SCHAFFER, LW
    SCHORN, TW
    ZINGARO, GJ
    CHANG, RSL
    LOTTI, VJ
    KIVLIGHN, SD
    SIEGL, PKS
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (01) : 115 - 120
  • [10] CHANG RSL, 1990, MOL PHARMACOL, V37, P347
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