RECENT OBSERVATIONS ON THE ROLE OF HEMOSTATIC DETERMINANTS IN THE DEVELOPMENT OF THE ATHEROTHROMBOTIC PLAQUE

被引：46

作者：

RABBANI, LE ^{[1
]}

LOSCALZO, J ^{[1
]}

机构：

[1] HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED, BROCKTON W ROXBURY VET ADM MED CTR,DEPT MED, BOSTON, MA 02115 USA

来源：

ATHEROSCLEROSIS | 1994年 / 105卷 / 01期

基金：

美国国家卫生研究院;

关键词：

FIBRINOGEN; LIPOPROTEIN(A); PLATELETS;

D O I：

10.1016/0021-9150(94)90002-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence suggests that hemostatic determinants play a major role in the evolution of the atherothrombotic plaque. Platelets can serve as cholesterol donors for macrophages, thereby facilitating foam cell formation. Lipoprotein(a) inhibits fibrinolysis and may also contribute to atherogenesis by serving as a ligand for the scavenger receptor. By complexing with fibrin(ogen) in atheromatous lesions, lipoprotein(a) attenuates clearance of this protein, promoting atherogenesis and vascular dysfunction. These observations suggest that thrombotic determinants are critical for the development of the atheromatous plaque, and may guide the appropriate selection of potential therapeutic options in the future.

引用

页码：1 / 7

页数：7

共 66 条

[1]

ABRAMS CS, 1990, BLOOD, V75, P128

[2] OLIGOSPECIFICITY OF THE CELLULAR ADHESION RECEPTOR MAC-1 ENCOMPASSES AN INDUCIBLE RECOGNITION SPECIFICITY FOR FIBRINOGEN [J].