THE REGULATORY ROLE OF TRIIODOTHYRONINE ON THE PRODUCTION OF ALPHA-FETOPROTEIN AND ALBUMIN BY MOUSE FETAL LIVER-CELLS

被引：11

作者：

ANTEBY, E

SHPAN, P

DUSHNIK, M

ZVANG, A

ZER, T

BENNERIAH, Z

YAGEL, S

机构：

[1] HADASSAH MT SCOPUS,DEPT OBSTET & GYNAECOL,POB 24035,JERUSALEM,ISRAEL

[2] HADASSAH MT SCOPUS,MOLEC BIOL UNIT,JERUSALEM,ISRAEL

[3] HADASSAH EIN KAREM,DEPT GENET,JERUSALEM,ISRAEL

[4] ZER LAB,JERUSALEM,ISRAEL

来源：

HUMAN REPRODUCTION | 1993年 / 8卷 / 10期

关键词：

ALBUMIN; ALPHA-FETOPROTEIN; HEPATOCYTES; MOUSE; TRIIODOTHYRONINE;

D O I：

10.1093/oxfordjournals.humrep.a137894

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The purpose of this study was to assess possible effects of triiodothyronine (T3) on the production of alpha fetoprotein (AFP) and albumin by mouse fetal liver cells. AFP from serum-free conditioned media of TIB73 mouse fetal liver cells was measured by immunoradiometric assay and albumin was measured by chromogenic assay. The expression of mRNAs was quantified by Northern blotting analysis. A marked inhibition of AFP secretion was found as well as an increase in albumin produced by T3 in a dose-dependent manner. The effects of T3 AFP and albumin secretion paralleled the effects of T3 on the steady-state expression of mRNAs encoding albumin and AFP. These data may point to a possible role of T3 in the transcriptional switch from AFP to albumin during fetal development and may explain the observation of high levels of AFP in cases of congenital hypothyroidism.

引用

页码：1576 / 1578

页数：3

共 11 条

[1] INCREASED MATERNAL SERUM ALPHA-FETOPROTEIN IN CONGENITAL HYPOTHYROIDISM [J].