POSSIBLE SOLUTION TO DISCORD BETWEEN VOID VOLUME RECOVERY OF POLYPEPTIDE AND SEPARATION OF DRUGS WITH RESTRICTED-ACCESS TYPE POLYMER-BASED SEPARATION MEDIA FOR HPLC

被引：1

作者：

HOSOYA, K ^{[1
]}

KISHII, Y ^{[1
]}

TANAKA, N ^{[1
]}

KIMATA, K ^{[1
]}

ARAKI, T ^{[1
]}

KINIWA, H ^{[1
]}

机构：

[1] MITSUBISHI KASEI CO, RES CTR, MIDORI KU, YOKOHAMA 227, JAPAN

来源：

CHEMISTRY LETTERS | 1993年 / 04期

关键词：

D O I：

10.1246/cl.1993.745

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Size monodisperse restricted-access and permeable polymer-based separation media were prepared and utilized as HPLC packing materials for void volume recovery of polypeptides and chromatographic separation of drugs. Restricted-access polymer-based packing material gave quantitative recovery of the polypeptide, but separation of some drugs was very poor, while permeable packing material with sufficiently large pores showed good recovery of the polypeptide and also excellent separation of the drugs.

引用

页码：745 / 748

页数：4

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