PALM CAROTENE INHIBITS TUMOR-PROMOTING ACTIVITY OF BILE-ACIDS AND INTESTINAL CARCINOGENESIS

被引：0
作者：
OKUZUMI, J
NISHINO, H
MURAKOSHI, M
YAMANE, T
KITAO, Y
INAGAKE, M
OHYA, K
YOSHIDA, M
TAKAHASHI, T
机构：
[1] KYOTO PREFECTURAL UNIV MED, DEPT SURG 1, KAMIKYO KU, KYOTO 602, JAPAN
[2] KYOTO PREFECTURAL UNIV MED, DEPT BIOCHEM, KAMIKYO KU, KYOTO 602, JAPAN
[3] KYOTO PREFECTURAL UNIV MED, DEPT PREVENT MED, KAMIKYO KU, KYOTO 602, JAPAN
[4] LION CORP, EDOGAWA KU, TOKYO, JAPAN
来源：
ONCOLOGY | 1992年 / 49卷 / 06期
关键词：
PALM CAROTENE; BILE ACIDS; INTESTINAL CARCINOGENESIS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effects of palm carotene on chemical carcinogenesis was studied. Palm carotene suppressed mouse epidermal ornithine decarboxylase activity induced by glycocholic acid. In a two-stage mouse epidermal carcinogenesis experiment using 7,12-dimethylbenz(a)anthracene as the initiator, glycocholic acid as the 1st stage promoter, and mezerein as the 2nd stage promoter, palm carotene inhibited the promoting activity of glycocholic acid. Furthermore, in N-ethyl-N'-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis, 0.05% of palm carotene given in drinking water decreased the percentage of tumor-bearing mice significantly.
引用
收藏
页码：492 / 497
页数：6
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