EXPRESSION OF THE WILMS-TUMOR GENE (WT1) IN HUMAN LEUKEMIAS

被引：0
|
作者：
MIWA, H
BERAN, M
SAUNDERS, GF
机构：
[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT BIOCHEM & MOLEC BIOL,HOUSTON,TX 77030
[2] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEMATOL,HOUSTON,TX 77030
来源：
LEUKEMIA | 1992年 / 6卷 / 05期
关键词：
D O I：
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Leukemic cells from seventy patients with various types of human leukemias were examined for expression of the WT1 gene, the Wilms' tumor gene located at chromosome 11p13. WT1 was expressed in 7 of 16 cases of acute lymphoblastic leukemia, 15 of 22 with acute myelogenous leukemia and 8 of 10 in blast crisis of chronic myelogenous leukemia. No detectable WT1 RNA was found in chronic leukemias, including chronic lymphocytic leukemia, plasma cell leukemia, hairy cell leukemia and chronic myelogenous leukemia in chronic phase. The expression pattern of WT1 in these human leukemia samples indicates the involvement of this gene in the early stage of hematological cell differentiation.
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页码：405 / 409
页数：5
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