GENERATION OF CHROMOSOME SIZE POLYMORPHISM DURING INVIVO MITOTIC MULTIPLICATION OF PLASMODIUM-BERGHEI INVOLVES BOTH LOSS AND ADDITION OF SUBTELOMERIC REPEAT SEQUENCES

被引：64
作者：
PONZI, M
JANSE, CJ
DORE, E
SCOTTI, R
PACE, T
RETERINK, TJF
VANDERBERG, FM
MONS, B
机构：
[1] UNIV LEIDEN,PARASITOL LAB,LEIDEN,NETHERLANDS
[2] UNIV AMSTERDAM,DEPT PATHOL,AMSTERDAM,NETHERLANDS
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1990年 / 41卷 / 01期
关键词：
Chromosome polymorphism; Plasmodium berghei; Subtelomeric repeats;
D O I：
10.1016/0166-6851(90)90098-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extensive chromosome size polymorphism arises in Plasmodium berghei during in vivo mitotic multiplication. Size differences between homologous chromosomes involve rearrangements occurring in the subtelomeric portions while internal chromosomal regions do not contribute significantly to chromosome size polymorphism. Differences in the copy number of a 2.3-kb subtelomeric repeated unit are shown to correlate with size variations, and in at least one case to account completely for the size difference between two variants of the same chromosome. © 1990.
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页码：73 / 82
页数：10
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