STRUCTURE OF SNAKE TOXINS AND THEIR AFFINITY TO ACETYLCHOLINE-RECEPTOR OF FISH ELECTRIC ORGAN

被引：66
作者：
ISHIKAWA, Y [1 ]
MENEZ, A [1 ]
HORI, H [1 ]
YOSHIDA, H [1 ]
TAMIYA, N [1 ]
机构：
[1] TOHOKU UNIV, DEPT CHEM, SENDAI, MIYAGI 980, JAPAN
来源：
TOXICON | 1977年 / 15卷 / 06期
关键词：
D O I：
10.1016/0041-0101(77)90098-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The affinity of sea snake [Laticouda semifasciata, Aipysuru laevis] and elapid snake [Burgorus multicinctus] venom components with neurotoxic activity, and their chemically modified derivatives, to the acetylcholine receptor of ray (Torpedo marmorata) electric organ was studied by following the competition in binding with labeled toxin .alpha. Naja nigricollis venom. Some of the unusual toxins, which lack some of the invariant residues among neurotoxins, have lower affinity. A parallel relationship between the affinity and LD50 was observed.
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页码：477 / 488
页数：12
相关论文
共 52 条
[1]   ACETYLCHOLINE-RECEPTOR IN NORMAL AND DENERVATED SLOW AND FAST MUSCLE [J].
ALMON, RR ;
ANDREW, CG ;
APPEL, SH .
BIOCHEMISTRY, 1974, 13 (27) :5522-5528
[2]   AMINO-ACID SEQUENCE OF OXIANA ALPHA MAIN NEUROTOXIN OF VENOM OF NAJA-NAJA-OXIANA [J].
ARNBERG, H ;
EAKER, D ;
FRYKLUND, L ;
KARLSSON, E .
BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 359 (02) :222-232
[3]   PRIMARY SEQUENCES AND NEUROMUSCULAR EFFECTS OF 3 NEUROTOXIC POLYPEPTIDES FROM VENOM OF DENDROASPIS-VIRIDIS [J].
BANKS, BEC ;
MILEDI, R ;
SHIPOLINI, RA .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1974, 45 (02) :457-468
[4]   CHOLINERGIC RECEPTOR MOLECULES AND CHOLINESTERASE MOLECULES AT MOUSE SKELETAL MUSCLE JUNCTIONS [J].
BARNARD, EA ;
WIECKOWSKI, J ;
CHIU, TH .
NATURE, 1971, 234 (5326) :207-+
[5]   BINDING OF ALPHA-BUNGAROTOXIN TO ACETYLCHOLINE RECEPTORS IN MAMMALIAN MUSCLE [J].
BERG, DK ;
KELLY, RB ;
SARGENT, PB ;
WILLIAMSON, P ;
HALL, ZW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (01) :147-+
[6]   MOLECULAR PROPERTIES OF CHOLINERGIC RECEPTOR PURIFIED FROM ELECTROPHORUS-ELECTRICUS [J].
BIESECKE.G .
BIOCHEMISTRY, 1973, 12 (22) :4403-4409
[7]   LOCALIZATION OF CHOLINERGIC RECEPTOR PROTEIN IN ELECTROPHORUS ELECTROPLAX BY HIGH-RESOLUTION AUTORADIOGRAPHY [J].
BOURGEOIS, JP ;
BOQUET, P ;
CHANGEUX, JP ;
RYTER, A ;
MENEZ, A ;
FROMAGEOT, P .
FEBS LETTERS, 1972, 25 (01) :127-+
[8]   SNAKE-VENOM TOXINS - ISOLATION AND PURIFICATION OF 3 CYTOTOXIN HOMOLOGS FROM VENOM OF FOREST COBRA (NAJA-MELANOLEUCA) AND COMPLETE AMINO-ACID SEQUENCE OF TOXIN VII1 [J].
CARLSSON, FH ;
JOUBERT, FJ .
BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 336 (02) :453-469
[9]  
CHANG CC, 1963, ARCH INT PHARMACOD T, V144, P241
[10]   PURIFICATION AND CHARACTERIZATION OF ACETYLCHOLINE RECEPTOR-I FROM ELECTROPHORUS-ELECTRICUS [J].
CHANG, HW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (05) :2113-2117
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