ANTIBIOTIC-RESISTANCE IN STAPHYLOCOCCI ADHERENT TO CORTICAL BONE

被引：20

作者：

WEBB, LX

HOLMAN, J

DEARAUJO, B

ZACCARO, DJ

GORDON, ES

机构：

[1] Departments of Orthopaedic Surgery, The Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC

[2] Public Health Sciences, The Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC

来源：

JOURNAL OF ORTHOPAEDIC TRAUMA | 1994年 / 8卷 / 01期

关键词：

STAPHYLOCOCCI; CORTICAL BONE; ANTIBIOTIC RESISTANCE;

D O I：

10.1097/00005131-199402000-00007

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The surface-adherent mode of bacterial growth has been shown to play a pivotal role in the persistent nature of infections involving retained foreign bodies, biomaterials, or dead bone (e.g., osteomyelitis). The hypothesis tested herein is that bone and implant materials-polytetrafluoroethylene (PTFE), and polymethylmethacrylate (PMMA)-provide a surface environment that promotes a type of bacterial growth characterized by an enhanced antibiotic resistance. The antibiotic resistance estimates of three staphylococcal subtypes were determined for organisms grown in an adherent state on the aforementioned surfaces as well as in their nonadherent or suspended state. Antibiotic resistance was found to vary with mode of bacterial growth. Secondly, for the staphylococcal subtypes, antibiotics and modes of growth studied herein, adherent growth on bone was associated with the most antibiotic resistance.

引用

页码：28 / 33

页数：6

共 38 条

[1]

Adherent bacterial colonization in the pathogenesis of osteomyelitis, Science, 228, pp. 990-993, (1992)

[2]

Anwar H., Strap J.L., Costerton J.W., Minireview establishment of aging biofilms: Possible mechanism of bacterial resistance to antimicrobial therapy, Antimicrob Agents Chemother July, pp. 1347-1351, (1992)

[3]

Baltimore R.S., Mitchell M., Immunologic investigations of mucoid strains of Pseudomonas aeruginosa: Comparison of susceptibility to opsonic antibody in mucoid and nonmucoid strains, J Infect Dis, 141, pp. 238-247, (1980)

[4]

Barnett R.N., Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, (1985)

[5]

Bayston R., Penny S.R., Excessive production of mucoid substance in Staphylococcus SIIA: A possible factor in colonisation of Holter shunts, Dev Med Child Neurol, 14, pp. 25-28, (1972)

[6]

Burke D.W., Gates E.I., Harris W.H., Centrifugation as a method of improving tensile and fatigue properties of acrylic bone cement, J Bone Joint Surg [Am], 66, pp. 1265-1273, (1984)

[7]

Costerton J.W., Geesey G.G., Surface Contamination, pp. 211-221, (1979)

[8]

Costerton J.W., Geesey G.G., Cheng K.J., How bacteria stick, Sci Am, 238, pp. 86-95, (1973)

[9]

Costerton J.W., Irvin R.T., The bacterial glycocalyx in nature and disease, Annu Rev Microbiol, 35, pp. 299-324, (1981)

[10]

Costerton J.W., Irvin R.T., Cheng K.J., The bacterial glycocalyx in nature and disease, Annu Rev Microbiol, 35, pp. 299-324, (1981)

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