DISTRIBUTION OF NMDA RECEPTOR-BINDING IN DEVELOPING MOUSE SPINAL-CORD

被引：53
|
作者：
GONZALEZ, DL
FUCHS, JL
DROGE, MH
机构：
[1] UNIV N TEXAS, DEPT BIOL SCI, DENTON, TX 76203 USA
[2] TEXAS WOMANS UNIV, DEPT BIOL, DENTON, TX 76204 USA
来源：
NEUROSCIENCE LETTERS | 1993年 / 151卷 / 02期
关键词：
N-METHYL-D-ASPARTATE; ONTOGENY; GLUTAMATE; SUBSTANTIA-GELATINOSA; RECEPTOR AUTORADIOGRAPHY;
D O I：
10.1016/0304-3940(93)90004-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The role of NMDA receptors in spinal sensorimotor processes has been studied in neonates and adults, while NMDA binding has previously been described only in mature spinal cord. In autoradiographs of mouse lumbar cord, NMDA-sensitive [H-3]glutamate binding peaked transiently around postnatal days 6-10. Differentiation increased progressively from day 10 to adulthood. Mature levels were highest in substantia gelatinosa and moderate in dorsomedial dorsal horn. The results are described in relation to functional and anatomical features of developing spinal cord.
引用
收藏
页码：134 / 137
页数：4
相关论文
共 50 条
  • [41] DISTRIBUTION OF GALANIN MESSENGER-RNA CONTAINING CELLS AND GALANIN RECEPTOR-BINDING SITES IN HUMAN AND RAT HYPOTHALAMUS
    BONNEFOND, C
    PALACIOS, JM
    PROBST, A
    MENGOD, G
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1990, 2 (07) : 629 - 637
  • [42] Immunolocalization of NMDA receptor subunit NR3B in selected structures in the rat forebrain, cerebellum, and lumbar spinal cord
    Wee, Karen S. -L.
    Zhang, Yibin
    Khanna, Sanjay
    Low, Chian-Ming
    JOURNAL OF COMPARATIVE NEUROLOGY, 2008, 509 (01) : 118 - 135
  • [43] A POTENT METABOTROPIC GLUTAMATE RECEPTOR AGONIST - ELECTROPHYSIOLOGICAL ACTIONS OF A CONFORMATIONALLY RESTRICTED GLUTAMATE ANALOG IN THE RAT SPINAL-CORD AND XENOPUS OOCYTES
    ISHIDA, M
    AKAGI, H
    SHIMAMOTO, K
    OHFUNE, Y
    SHINOZAKI, H
    BRAIN RESEARCH, 1990, 537 (1-2) : 311 - 314
  • [44] Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption
    Narita, Minoru
    Miyoshi, Kan
    Narita, Michiko
    Suzuki, Tsutomu
    LIFE SCIENCES, 2007, 80 (09) : 852 - 859
  • [45] NK1, NMDA, 5HT1a, and 5HT2 receptor binding sites in the rat lumbar spinal cord: Modulation following sciatic nerve crush
    Croul, S
    Radzievsky, A
    Sverstiuk, A
    Murray, M
    EXPERIMENTAL NEUROLOGY, 1998, 154 (01) : 66 - 79
  • [46] NMDA receptor blockage with 2-amino-5-phosphonovaleric acid improves oxidative stress after spinal cord trauma in rats
    Vural, M.
    Arslantas, A.
    Yazihan, N.
    Koken, T.
    Uzuner, K.
    Arslantas, D.
    Ozbek, Z.
    SPINAL CORD, 2010, 48 (04) : 285 - 289
  • [47] Constitutive KCC2 Cell- and Synapse-Speci fi cally Regulates NMDA Receptor Activity in the Spinal Cord
    Huang, Yuying
    Chen, Hong
    Shao, Jian-Ying
    Zhou, Jing-Jing
    Chen, Shao-Rui
    Pan, Hui -Lin
    JOURNAL OF NEUROSCIENCE, 2024, 44 (04)
  • [48] Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity
    Kohno, Tatsuro
    Wang, Haibin
    Amaya, Fumimasa
    Brenner, Gary J.
    Cheng, Jen-Kun
    Ji, Ru-Rong
    Woolf, Clifford J.
    JOURNAL OF NEUROSCIENCE, 2008, 28 (17) : 4533 - 4540
  • [49] Regional and cellular distribution of low affinity neurotensin receptor mRNA in adult and developing mouse brain
    Sarret, P
    Beaudet, A
    Vincent, JP
    Mazella, J
    JOURNAL OF COMPARATIVE NEUROLOGY, 1998, 394 (03) : 344 - 356
  • [50] SYMPATHETIC PREGANGLIONIC NEURONS IN NEONATAL RAT SPINAL-CORD INVITRO - ELECTROPHYSIOLOGICAL CHARACTERISTICS AND THE EFFECTS OF SELECTIVE EXCITATORY AMINO-ACID RECEPTOR AGONISTS
    SPANSWICK, D
    LOGAN, SD
    BRAIN RESEARCH, 1990, 525 (02) : 181 - 188
12345