DISTRIBUTION OF NMDA RECEPTOR-BINDING IN DEVELOPING MOUSE SPINAL-CORD

被引：53
|
作者：
GONZALEZ, DL
FUCHS, JL
DROGE, MH
机构：
[1] UNIV N TEXAS, DEPT BIOL SCI, DENTON, TX 76203 USA
[2] TEXAS WOMANS UNIV, DEPT BIOL, DENTON, TX 76204 USA
来源：
NEUROSCIENCE LETTERS | 1993年 / 151卷 / 02期
关键词：
N-METHYL-D-ASPARTATE; ONTOGENY; GLUTAMATE; SUBSTANTIA-GELATINOSA; RECEPTOR AUTORADIOGRAPHY;
D O I：
10.1016/0304-3940(93)90004-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The role of NMDA receptors in spinal sensorimotor processes has been studied in neonates and adults, while NMDA binding has previously been described only in mature spinal cord. In autoradiographs of mouse lumbar cord, NMDA-sensitive [H-3]glutamate binding peaked transiently around postnatal days 6-10. Differentiation increased progressively from day 10 to adulthood. Mature levels were highest in substantia gelatinosa and moderate in dorsomedial dorsal horn. The results are described in relation to functional and anatomical features of developing spinal cord.
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页码：134 / 137
页数：4
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