ESCHERICHIA-COLI AND SACCHAROMYCES-CEREVISIAE ACETYLORNITHINE AMINOTRANSFERASES - EVOLUTIONARY RELATIONSHIP WITH ORNITHINE AMINOTRANSFERASES

被引：53
作者：
HEIMBERG, H
BOYEN, A
CRABEEL, M
GLANSDORFF, N
机构：
[1] CERIA,COOVI,RES INST,1 AVE E GRYSON,B-1070 BRUSSELS,BELGIUM
[2] VRIJE UNIV BRUSSELS,B-1070 BRUSSELS,BELGIUM
来源：
GENE | 1990年 / 90卷 / 01期
关键词：
arginine; homology; nucleotide sequence; Recombinant DNA; substrate ambiguity; transaminases;
D O I：
10.1016/0378-1119(90)90440-3
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Genes argD and ARG8, encoding the acetylornithine aminotransferase (ACOAT) subunit in Escherichia coli and Saccharomyces cerevisiae, respectively, have been cloned and sequenced. The deduced amino acid sequences show substantial similarity. Moreover, they resemble ornithine aminotransferase (OAT) sequences (i.e., those from yeast, rat and man); the observed similarities are statistically significant, indicating that the enzymes are homologous. However, in contrast to OATs, which appear to be substrate (i.e., ornithine)-specific, S. cerevisiae ACOAT transaminates ornithine about as efficiently as E. coli does. The evolutionary relationship between ACOATs and OATs is discussed in terms of substrate ambiguity. © 1990.
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页码：69 / 78
页数：10
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