QUANTITATIVE DEPENDENCE OF MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION ON OXYGEN CONCENTRATION - MATHEMATICAL-MODEL

被引：149
作者：
WILSON, DF [1 ]
OWEN, CS [1 ]
ERECINSKA, M [1 ]
机构：
[1] UNIV PENN,SCH MED,DEPT PHARMACOL,PHILADELPHIA,PA 19104
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1979年 / 195卷 / 02期
关键词：
D O I：
10.1016/0003-9861(79)90376-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The model of Wilson and co-workers (D. F. Wilson, C. S. Owen, and A. Holian, 1977, Arch. Biochem. Biophys. 182, 749-762) for the regulation of mitochondrial oxidative phosphorylation has been extended to include the dependence on oxygen tension. The derived rate expression correctly describes the observed dependence of cellular energy metabolism on oxygen tension, including the oxygen dependence at normoxic" physiological values. Experimental evidence is presented that oxidative phosphorylation by suspensions of isolated rat liver mitochondria is also dependent on oxygen concentration up to values of at least 100 μM. © 1979."
引用
收藏
页码：494 / 504
页数：11
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