Study of Candida Bloodstream Infections in Surgical Intensive Care Unit Patients and Susceptibility Profile of the Isolates

被引:0
作者
Rajmane, Vijaya S. [1 ]
Rajmane, Shivkumar T. [2 ]
Mohite, Shivaji T. [3 ]
Raje, Vinayak V. [4 ]
机构
[1] Shree Chhatrapati Shivaji Educ Soc Inst Med Sci &, Dept Microbiol, Mayani 415102, Maharashtra, India
[2] Shree Chhatrapati Shivaji Educ Soc Inst Med Sci &, Dept Orthopaed, Mayani 415102, Maharashtra, India
[3] Krishna Inst Med Sci Univ, Dept Microbiol, Karad 415539, Maharashtra, India
[4] Krishna Inst Med Sci Univ, Dept Neurosurg, Karad 415539, Maharashtra, India
关键词
Antifungal Susceptibility Testing; Candidemia; Risk factors;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The increased incidence of fungal infections in the past two decades has been overwhelming. Despite the fact that invasive fungal infections are still under-diagnosed and under-reported, bloodstream infection due to Candida is now being recognized as an important public health problem especially in ICU patients with considerable morbidity, mortality and health care costs. Objective: To study the incidence, risk factors and antifungal susceptibility of Candida bloodstream infection in our hospital. Material and Methods: In the present study, the blood samples were collected from patients admitted in Surgical ICU. Samples were processed and antifungal susceptibility of the isolates was performed using standard protocol. Results: Out of total 93 patients, 14 (15.05%) were positive for candidemia with equal distribution of both C. albicans and non-albicans Candida spp. The risk factors associated with candidemia showing statistical significance were length of ICU stay > 7 days, mechanical ventilation, central venous catheters and uncontrolled diabetes. Among the patients with candidemia the mortality rate was 78.57 %. Resistance to Amphotericin B was seen in 33.33 % isolates of C. tropicalis and 100 % isolates of C. rugosa. 33.33 % of C. tropicalis and 50 % of C. rugosa showed dose dependent susceptibility to Fluconazole. Conclusion: Early diagnosis and antifungal susceptibility testing is very important in the treatment of candidemia for reducing the mortality rate.
引用
收藏
页码:82 / 88
页数:7
相关论文
共 29 条
[1]   Species distribution and anti-fungal susceptibility of Candidaemia at a multi super-specialty center in southern India [J].
Adhikary, R. ;
Joshi, S. .
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2011, 29 (03) :309-311
[2]  
AlSoub H, 1997, J HOSP INFECT, V35, P141, DOI 10.1016/S0195-6701(97)90102-X
[3]  
Arora Deepak, 2011, INT J PHARM PHARM SC, V3, P157
[4]   Epidemiological trends in nosocomial candidemia in intensive care [J].
Bassetti, M ;
Righi, E ;
Costa, A ;
Fasce, R ;
Molinari, MP ;
Rosso, R ;
Pallavicini, FB ;
Viscoli, C .
BMC INFECTIOUS DISEASES, 2006, 6 (1)
[5]   Risk factors for candidal bloodstream infections in surgical intensive care unit patients: The NEMIS Prospective Multicenter Study [J].
Blumberg, HM ;
Jarvis, WR ;
Soucie, JM ;
Edwards, JE ;
Patterson, JE ;
Pfaller, MA ;
Rangel-Frausto, MS ;
Rinaldi, MG ;
Saiman, L ;
Wiblin, RT ;
Wenzel, RP .
CLINICAL INFECTIOUS DISEASES, 2001, 33 (02) :177-186
[6]  
Chakrabarti A, 2012, CANDIDEMIA INTENSIVE
[7]  
Chander J., 2002, TXB MED MYCOLOGY
[8]   Factors associated with candidemia caused by non-albicans Candida species versus Candida albicans in the intensive care unit [J].
Chow, Jennifer K. ;
Golan, Yoav ;
Ruthazer, Robin ;
Karchmer, Adolf W. ;
Carmeli, Yehuda ;
Lichtenberg, Deborah ;
Chawla, Varun ;
Young, Janet ;
Hadley, Susan .
CLINICAL INFECTIOUS DISEASES, 2008, 46 (08) :1206-1213
[9]   Study of risk factors and prevalence of invasive candidiasis in a tertiary care hospital [J].
Chowta, Mukta N. ;
Adhikari, Prabha ;
Rajeev, A. ;
Shenoy, Ashok K. .
INDIAN JOURNAL OF CRITICAL CARE MEDICINE, 2007, 11 (02) :67-73
[10]  
CLSI, 2018, M38 CLSI