ANTIBODY-INDUCED MODULATION OF FRIEND-VIRUS CELL-SURFACE ANTIGENS DECREASES VIRUS PRODUCTION BY PERSISTENT ERYTHROLEUKEMIA-CELLS - INFLUENCE OF THE RFV-3 GENE

被引：52
作者：
CHESEBRO, B
WEHRLY, K
DOIG, D
NISHIO, J
机构：
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 11期
关键词：
D O I：
10.1073/pnas.76.11.5784
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Rfv-3 gene influenced the level of Friend leukemia virus production in spleens of leukemic mice later than 30 days after virus inoculation. Rfv-3r/s mice [(B10.A .times. A)F1 and (B10.A .times. A.BY)F1] had decreased spleen virus levels 30-90 days after virus inoculation compared to Rfv-3s/s mice [A.BY, A, BALB.B, and (BALB/c .times. A)F1)]. In (B10.A .times. A)F1 .times. A backcross mice the spleen virus titer segregated with the level of viremia. The Rfv-3 gene appeared to act by controlling anti/Friend virus antibody production. The interaction of antiviral antibody with infected cells led to a decrease in release of infectious virus by late leukemic spleen cells in Rfv-3r/s mice to 1/300th that in Rfv-3s/s mice. This decrease in virus release appeared to be due to interference with the virus budding process due to antibody-mediated modulation of virus-induced cell surface antigens.
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页码：5784 / 5788
页数：5
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