HUMAN-PERFORMANCE AND PHYSIOLOGICAL-FUNCTION DURING A 24-HR EXPOSURE TO 1-PERCENT BROMOTRIFLUOROMETHANE (HALON-1301)

Human Performance and Physiological Function during a 24-hr Exposure to 1% Bromotrifluoromethane (Halon 1301). Calkins, D. S., Degioanni, J. J., Tan, M. N., Davis, J. R., and Pierson, D. L. (1993). Fundam. Appl. Toxicol. 20, 240-247. Performance and physiological measurements were obtained from four pairs or men exposed for 24 hr to 1% (10,000 ppm) Halon 1301 (bromotrifluoromethane, CBrF3) and to air with order counterbalanced using a double-blind protocol, Cognitive and motor performance was assessed before, during, and after the exposures using seven scales of the Automated Portable Testing System, which produced 13 measures of performance. Halon inhalation induced decrements in 2 of the 13 measures, but actual and estimated magnitudes of the decrements were no greater than 5% of baseline values. Physiological data were obtained before, during, and after the exposures from clinical chemistry analyses of blood and urine samples, pulmonary function tests, and monitoring of vital signs. Significant change during Halon inhalation was observed for 6 of the 52 variables assessed; however, all physiological values remained within clinically acceptable limits. No cardiovascular effects were noted. This study demonstrated that exposure to 1% Halon 1301 for 24 hr can produce minor disturbance of central nervous system function as assessed by cognitive tasks. © 1993 Society of Toxicology.