EFFECTS OF INTERLEUKIN-1 RECEPTOR ANTAGONIST ON THE BEHAVIORAL-EFFECTS OF LIPOPOLYSACCHARIDE IN RAT

被引：240

作者：

BLUTHE, RM ^{[1
]}

DANTZER, R ^{[1
]}

KELLEY, KW ^{[1
]}

机构：

[1] UNIV ILLINOIS,DEPT ANIM SCI,PLANT & ANIM BIOTECHNOL LAB,URBANA,IL 61801

来源：

BRAIN RESEARCH | 1992年 / 573卷 / 02期

关键词：

LIPOPOLYSACCHARIDE; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR ANTAGONIST; SOCIAL BEHAVIOR; RAT;

D O I：

10.1016/0006-8993(92)90779-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the role of interleukin-1 (IL-1) in lipopolysaccharide (LPS)-induced sickness behavior, rats were injected with recombinant human interleukin-1 receptor antagonist (IL-1ra), an endogenous cytokine able to block most of the biological effects of IL-1 both in vivo and in vitro. Intraperitoneal injection of IL-1ra (3 mg/rat) attenuated the depressive effect of LPS (250-mu-g/kg) on social exploration and body weight when both treatments were injected peripherally. Intracerebroventricular injection of IL-1ra (60-mu-g/rat) did not block the effects of peripherally injected LPS. These data indicate that the peripherally mediated effects of IL-1 account for a significant part of LPS-induced sickness behavior.

引用

页码：318 / 320

页数：3

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