EFFECT OF CIGARETTE-SMOKE ON DRUG-METABOLISM INVITRO

被引：3

作者：

GARRETT, RJB ^{[1
]}

JACKSON, MA ^{[1
]}

FILIO, AK ^{[1
]}

GARRETT, NE ^{[1
]}

机构：

[1] UNIV KENTUCKY,COLL PHARM,LEXINGTON,KY 40506

来源：

LIFE SCIENCES | 1979年 / 25卷 / 09期

关键词：

D O I：

10.1016/0024-3205(79)90519-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

N-demethylation of aminopyrine and C-hydroxylation of aniline by hepatic microsomal enzymes were measured during in vitro exposure to cigarette smoke. Metabolism of aminopyrine during smoke exposure was not significantly altered. Metabolism of aniline during smoke exposure was inhibited 70-80% (P < .001) thus indicating that an initial effect of exposure to cigarette smoke is a decreased rate of biotransformation via C-hydroxylation. This finding, coupled with the findings of other investigators who have shown that the delayed effect of exposure to cigarette smoke is induction of hydroxylase activity, suggests that cigarette smoke produces a biphasic alteration in certain hepatic biotransformation processes. © 1979.

引用

页码：755 / 758

页数：4

共 23 条

[1] INDUCTION OF ARYL-HYDROCARBON HYDROXYLASE IN RODENT LUNG BY CIGARETTE-SMOKE - POTENTIAL SHORT-TERM BIOASSAY [J].