Transcription control by long non-coding RNAs

被引：27

作者：

Faust, Tyler ^{[1
]}

Frankel, Alan D. ^{[1
]}

D'Orso, Ivan ^{[2
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA

来源：

TRANSCRIPTION-AUSTIN | 2012年 / 3卷 / 02期

关键词：

chromatin; epigenetic silencing; large intergenic non-coding RNAs; long non-coding RNAs; RNA polymerase II; transcription;

D O I：

10.4161/trns.19349

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N on-coding RNAs have been found to regulate many cellular processes and thus expand the functional genetic repertoire contained within the genome. With the recent advent of genomic tools, it is now evident that these RNA molecules play central regulatory roles in many transcriptional programs. Here we discuss how they are targeted to promoters in several cases and how they operate at specific points in the transcription cycle to precisely control gene expression.

引用

页码：78 / 86

页数：9

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