The Immunohistochemical Expression of Matrix Metalloproteinases-2 and -9 in Low-Grade Appendiceal Mucinous Neoplasms: May These Neoplasms be Non-Invasive?

被引：1

作者：

Ekinci, Ozgur ^{[1
]}

机构：

[1] Gazi Univ, Dept Med Pathol, Fac Med, Ankara, Turkey

来源：

GAZI MEDICAL JOURNAL | 2018年 / 29卷 / 02期

关键词：

Appendix; mucinous neoplasm; matrix metalloproteinase;

D O I：

10.12996/gmj.2018.34

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Low-grade appendiceal mucinous neoplasms (LAMN) are debated about their potential to cause invasion and pseudomyxoma peritoneii (PMxP). Our aim was to examine these neoplasms by two invasion markers: matrix metalloproteinases-2 and -9 (MMP). Methods: Twenty-eight cases of mucinous adenomas, LAMNs and adenocarcinomas were included. Immunohistochemistry of MMP-2 and -9 were applied and scored. Results: Overall, the majority of LAMNs were negative by these two markers. Conclusion: LAMNs may not actually have an invasive nature but still they can cause PMxP. These patients should be followed.

引用

页码：123 / 127

页数：5

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