SYNTHESIS OF 3'-O-(2-AMINOETHYL)-2'-DEOXYURIDINES

被引：2
|
作者：
ALEEM, AAHA
LARSEN, E
PEDERSEN, EB
NIELSEN, C
机构：
[1] ODENSE UNIV,DEPT CHEM,DK-5230 ODENSE M,DENMARK
[2] STATENS SERUM INST,DEPT VIROL,RETROVIRUS LAB,DK-2300 COPENHAGEN,DENMARK
来源：
ACTA CHEMICA SCANDINAVICA | 1995年 / 49卷 / 08期
关键词：
D O I：
10.3891/acta.chem.scand.49-0609
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Methyl 2-deoxy-3-O-[2-(formyl amino)ethyl]-5-O-trityl-D-erythro-pentofuranoside (4) was obtained in a 3-O alkylation reaction by treatment with 2-chloroethylamine in DMF. Compound 4 afforded or nucleosides as the main products when condensed with uracils under the Vorbruggen conditions. The nucleosides were deblocked by treatment with 80% acetic acid and subsequently with sodium methoxide in methanol.
引用
收藏
页码：609 / 614
页数：6
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