SYNTHESIS OF 3'-O-(2-AMINOETHYL)-2'-DEOXYURIDINES

被引：2

作者：

ALEEM, AAHA

LARSEN, E

PEDERSEN, EB

NIELSEN, C

机构：

[1] ODENSE UNIV,DEPT CHEM,DK-5230 ODENSE M,DENMARK

[2] STATENS SERUM INST,DEPT VIROL,RETROVIRUS LAB,DK-2300 COPENHAGEN,DENMARK

来源：

ACTA CHEMICA SCANDINAVICA | 1995年 / 49卷 / 08期

关键词：

D O I：

10.3891/acta.chem.scand.49-0609

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Methyl 2-deoxy-3-O-[2-(formyl amino)ethyl]-5-O-trityl-D-erythro-pentofuranoside (4) was obtained in a 3-O alkylation reaction by treatment with 2-chloroethylamine in DMF. Compound 4 afforded or nucleosides as the main products when condensed with uracils under the Vorbruggen conditions. The nucleosides were deblocked by treatment with 80% acetic acid and subsequently with sodium methoxide in methanol.

引用

页码：609 / 614

页数：6

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