A COMPREHENSIVE HUMAN LINKAGE WITH CENTIMORGAN DENSITY

被引：498

作者：

MURRAY, JC

BUETOW, KH

WEBER, JL

LUDWIGSEN, S

SCHERPBIERHEDDEMA, T

MANION, F

QUILLEN, J

SHEFFIELD, VC

SUNDEN, S

DUYK, GM

WEISSENBACH, J

GYAPAY, G

DIB, C

MORRISSETTE, J

LATHROP, GM

VIGNAL, A

WHITE, R

MATSUNAMI, N

GERKEN, S

MELIS, R

ALBERTSEN, H

PLAETKE, R

ODELBERG, S

WARD, D

DAUSSET, J

COHEN, D

CANN, H

机构：

[1] UNIV IOWA,DEPT PEDIAT,IOWA CITY,IA 52245

[2] UNIV IOWA,DEPT BIOL,IOWA CITY,IA 52245

[3] FOX CHASE CANC CTR,PHILADELPHIA,PA 19111

[4] MARSHFIELD MED RES FDN,MARSHFIELD,WI 54449

[5] HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115

[6] GENETHON,F-91100 EVRY,FRANCE

[7] CHU LAVAL,LAVAL G1K 7P4,PQ,CANADA

[8] INSERM,F-75010 PARIS,FRANCE

[9] UNIV UTAH,ECCLES INST HUMAN GENET,SALT LAKE CITY,UT

[10] YALE UNIV,DEPT GENET,NEW HAVEN,CT 06510

[11] CTR ETUD POLYMORPHISME HUMAIN,F-75010 PARIS,FRANCE

来源：

SCIENCE | 1994年 / 265卷 / 5181期

关键词：

D O I：

10.1126/science.8091227

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identify genes for inherited disorders. Through the collaborative efforts of three large groups generating microsatellite markers and the efforts of the 110 CEPH collaborators, a comprehensive human linkage map is presented here. consists of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map. Of these loci, 3617 are polymerase chain reaction-formatted short tandem repeat polymorphisms, and another 427 are genes. The map has markers at an average density of 0.7 centimorgan, providing a resource for ready transference to physical maps and achieving one of the first goals of the Human Genome Project-a comprehensive, high-density genetic map.

引用

页码：2049 / 2054

页数：6

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