NITRIC-OXIDE CAUSES CONTRACTION IN THE RAT ISOLATED SMALL-INTESTINE

被引：31

作者：

BARTHO, L ^{[1
]}

LEFEBRE, RA ^{[1
]}

机构：

[1] STATE UNIV GHENT,SCH MED,HEYMANS INST PHARMACOL,B-9000 GHENT,BELGIUM

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 01期

关键词：

SMALL INTESTINE; RAT; NITRIC OXIDE (NO); NANC; (NONADRENERGIC; NONCHOLINERGIC); NEUROTRANSMISSION; NITRIC OXIDE (NO)-INDUCED CONTRACTION;

D O I：

10.1016/0014-2999(94)90166-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of authentic nitric oxide (NO) was investigated on rat ileal myenteric plexus-longitudinal muscle strips in the presence of atropine. NO (10-(10) to 3 x 10(-6) M) caused a quick, transient contraction of the smooth muscle, with an optimum concentration of 10(-7) M, as well as a slower contraction with a higher optimum concentration. In preparations sub-maximally pre-contracted with 5-hydroxytryptamine, NO (10(-7) to 3 X 10(-6) M) also caused a quick relaxant response. These responses to NO (10(-6) M) were not influenced by tetrodotoxin, indicating a direct effect on the smooth muscle.

引用

页码：101 / 104

页数：4

共 10 条

[1] BLOCKADE OF NITRIC-OXIDE SYNTHASE INHIBITS NERVE-MEDIATED CONTRACTION IN THE RAT SMALL-INTESTINE [J].

BARTHO, L ;

KOCZAN, G ;

PETHO, G ;

MAGGI, CA .

NEUROSCIENCE LETTERS, 1992, 145 (01) :43-46

[2] EVIDENCE THAT PROSTAGLANDIN IS RESPONSIBLE FOR REBOUND-CONTRACTION FOLLOWING STIMULATION OF NON-ADRENERGIC, NON-CHOLINERGIC (PURINERGIC) INHIBITORY NERVES [J].

BURNSTOCK, G ;

COCKS, T ;

PADDLE, B ;

STASZEWSKABARCZAK, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1975, 31 (02) :360-362

[3] KEY ROLES OF NITRIC-OXIDE AND CYCLIC-GMP IN NONADRENERGIC AND NONCHOLINERGIC INHIBITION IN RAT ILEUM [J].

KANADA, A ;

HATA, F ;

SUTHAMNATPONG, N ;

MAEHARA, T ;

ISHII, T ;

TAKEUCHI, T ;

YAGASAKI, O .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 216 (02) :287-292

[4] CONTROL OF CORONARY VASCULAR TONE BY NITRIC-OXIDE [J].

KELM, M ;

SCHRADER, J .

CIRCULATION RESEARCH, 1990, 66 (06) :1561-1575

[5] INHIBITORY ACTION OF NORADRENALINE AND ADRENALINE ON ACETYLCHOLINE OUTPUT BY GUINEA-PIG ILEUM LONGITUDINAL MUSCLE STRIP [J].

PATON, WDM ;

VIZI, ES .

BRITISH JOURNAL OF PHARMACOLOGY, 1969, 35 (01) :10-&

[6] NITRERGIC TRANSMISSION - NITRIC-OXIDE AS A MEDIATOR OF NONADRENERGIC, NONCHOLINERGIC NEUROEFFECTOR TRANSMISSION [J].

RAND, MJ .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1992, 19 (03) :147-169

[7] NITRIC-OXIDE AS A MEDIATOR OF NONADRENERGIC NONCHOLINERGIC NEUROTRANSMISSION [J].

SANDERS, KM ;

WARD, SM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (03) :G379-G392

[8] ROLE OF NITRIC-OXIDE IN THE AUTONOMIC INNERVATION OF SMOOTH-MUSCLE [J].

SNEDDON, P ;

GRAHAM, A .

JOURNAL OF AUTONOMIC PHARMACOLOGY, 1992, 12 (06) :445-456

[9] ROLE OF NITRIC-OXIDE IN GASTROINTESTINAL AND HEPATIC-FUNCTION AND DISEASE [J].

STARK, ME ;

SZURSZEWSKI, JH .

GASTROENTEROLOGY, 1992, 103 (06) :1928-1949

[10] ROLE OF NITRIC-OXIDE IN ESOPHAGEAL PERISTALSIS IN THE OPOSSUM [J].

YAMATO, S ;

SPECHLER, SJ ;

GOYAL, RK .

GASTROENTEROLOGY, 1992, 103 (01) :197-204

← 1 →