Medicine's genomic and proteomics era

被引:0
作者
Villegas, Jaime Bernal [1 ]
Obando, Fernando Suarez [1 ]
机构
[1] Pontificia Univ Javeriana, Inst Genet Humana, Bogota, DC, Colombia
来源
UNIVERSITAS MEDICA | 2007年 / 48卷 / 02期
关键词
genomics; genome; proteome; metabolome; medical education;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present conception of disease, included in the interaction process genome-proteomemetabolome- environment, induces a reflection on the curricular content of the medicine career. The necessity of genomics in the understanding of the human nature and in the development of its diseases, is a process that will change the fundamental concepts of the practice, and will generate a vision of the clinical handling, based on a complexity that does not exclude the genetic nature of individuals, nor rejects the environmental influence in the physiopathological process. This complexity must be discussed throughout the training of a medical student.
引用
收藏
页码:104 / 117
页数:14
相关论文
共 29 条
[1]   Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer [J].
Boyer, J ;
Allen, WL ;
McLean, EG ;
Wilson, PM ;
McCulla, A ;
Moore, S ;
Longley, DB ;
Caldas, C ;
Johnston, PG .
CANCER RESEARCH, 2006, 66 (05) :2765-2777
[2]   Clinical proteomics: From biomarker discovery and cell signaling profiles to individualized personal therapy [J].
Calvo, KR ;
Liotta, LA ;
Petricoin, EF .
BIOSCIENCE REPORTS, 2005, 25 (1-2) :107-125
[3]  
Carlson Bruce M., 2002, Anatomical Record, V269, P89
[4]   MEASUREMENT OF FITNESS AND MUTATION RATE IN HUMAN POPULATIONS [J].
CHARLESWORTH, B ;
CHARLESWORTH, D .
ANNALS OF HUMAN GENETICS, 1973, 37 (OCT) :175-187
[5]   Applications of molecular diagnostics: Solid tumor genetics can determine clinical treatment protocols [J].
Cordon-Cardo, C .
MODERN PATHOLOGY, 2001, 14 (03) :254-257
[6]   A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS [J].
FEARON, ER ;
VOGELSTEIN, B .
CELL, 1990, 61 (05) :759-767
[7]   Developmental origins of disease paradigm: A mechanistic and evolutionary perspective [J].
Gluckman, PD ;
Hanson, MA .
PEDIATRIC RESEARCH, 2004, 56 (03) :311-317
[8]   Staging of colon and rectal cancer: from endoscopy to molecular markers [J].
Greene, FL .
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2006, 20 (Suppl 2) :475-478
[9]   Organisms in nature as a central focus for biology [J].
Greene, HW .
TRENDS IN ECOLOGY & EVOLUTION, 2005, 20 (01) :23-27
[10]  
Instituto de Genetica Humana, 2006, LA NUEV BIOL